In the realm of pharmaceutical research and drug development, understanding how the body processes a drug is as critical as understanding the drug's efficacy. This process, known as metabolism, often involves the transformation of the parent drug into various metabolites. For Nifedipine, a widely prescribed calcium channel blocker used to treat hypertension and angina, its metabolic fate has been extensively studied. One of the key players in this metabolic pathway is Oxidized Nifedipine (CAS 67035-22-7).

Oxidized Nifedipine, also sometimes referred to as Dehydro Nifedipine, is identified as a main Nifedipine metabolite found in human plasma. This transformation primarily occurs through the action of cytochrome P450 (CYP) enzyme isomers, specifically CYP3A4 and CYP3A5. These enzymes are vital for the detoxification and elimination of many drugs in the body. For researchers and product formulators, having access to high-purity reference standards of these metabolites is paramount for conducting accurate studies.

The significance of Oxidized Nifedipine lies in its utility for various research purposes. Pharmaceutical scientists utilize it to trace the metabolic pathways of Nifedipine, aiding in the development of safer and more effective drug formulations. It serves as a crucial reference standard for analytical methods designed to detect and quantify Nifedipine and its metabolites in biological samples, such as blood or urine. This is particularly important for pharmacokinetic studies, which aim to understand how a drug is absorbed, distributed, metabolized, and excreted (ADME) by the body.

Furthermore, understanding the activity or potential side effects of metabolites is also a key area of research. Some studies have indicated that metabolites can sometimes retain biological activity or even contribute to adverse effects. Therefore, having Oxidized Nifedipine readily available allows researchers to investigate these possibilities thoroughly.

For procurement, sourcing Oxidized Nifedipine (CAS 67035-22-7) requires partnering with a reliable manufacturer and supplier. Companies seeking to buy this pharmaceutical intermediate often look for high purity levels, typically 98% or more, to ensure the integrity of their research data. A reputable supplier from China can offer competitive pricing without compromising on quality, making it an attractive option for global pharmaceutical companies and research institutions. When you are looking to purchase this compound, ensure you inquire about product specifications, stability data, and reliable shipping options. The availability of a Certificate of Analysis (CoA) is also a critical indicator of a product's quality and compliance.

In conclusion, Oxidized Nifedipine is more than just a byproduct of Nifedipine metabolism; it is an indispensable tool for pharmaceutical research. Its role in elucidating drug pathways and ensuring quality control underscores the importance of its availability. For any organization involved in cardiovascular drug research or related fields, securing a consistent supply of high-purity Oxidized Nifedipine from a trusted manufacturer is a strategic step towards scientific advancement.