The efficient functioning of the kidneys is fundamental to maintaining overall health, filtering waste products and regulating bodily fluids. Assessing renal function often involves specialized tests, and among the most critical is the measurement of renal plasma flow (RPF). This is where 4-Aminohippuric Acid (PAH) plays a pivotal role. For professionals seeking to understand and utilize this key diagnostic agent, sourcing it from reliable suppliers is paramount.

What is Renal Plasma Flow (RPF)?

Renal plasma flow refers to the volume of blood plasma that passes through the kidneys per unit of time. It's a direct indicator of how well the kidneys are perfused with blood, which is essential for their filtration and secretory functions. Deviations in RPF can signal a variety of kidney diseases or conditions affecting blood circulation to the kidneys.

The Role of 4-Aminohippuric Acid (PAH) in RPF Measurement

4-Aminohippuric Acid (CAS 61-78-9) is the substance of choice for RPF measurement due to its unique pharmacokinetic properties. When administered intravenously, PAH is:

  • Filtered by the glomeruli: A portion of the circulating PAH is filtered from the blood into the renal tubules.
  • Actively secreted by the proximal tubules: A significant amount of PAH is secreted directly from the blood into the tubular fluid by specific transport mechanisms.
  • Minimally reabsorbed: Unlike many other substances, PAH is not significantly reabsorbed back into the bloodstream from the tubules.

These characteristics mean that almost all the plasma entering the kidneys containing PAH is cleared in a single pass. By measuring the concentration of PAH in the blood and urine over a specific period, clinicians can accurately calculate the effective renal plasma flow. This makes PAH clearance tests a powerful tool for diagnosing and monitoring kidney diseases.

Why is PAH Clearance Important for Kidney Health?

A reduced RPF can indicate decreased kidney perfusion, which might be caused by conditions like dehydration, shock, renal artery stenosis, or certain types of kidney disease. Conversely, changes in RPF can also reflect the effectiveness of treatments aimed at improving kidney function. Therefore, reliable access to high-quality 4-Aminohippuric Acid is crucial for healthcare providers and researchers. Companies looking to buy this compound for diagnostic kits or research applications should seek out established manufacturers who guarantee purity and consistent performance.

Sourcing PAH from Reputable Suppliers

As a leading manufacturer and supplier of pharmaceutical-grade chemicals in China, we offer premium 4-Aminohippuric Acid (CAS 61-78-9). Our product is manufactured under strict quality control, ensuring the high purity required for accurate diagnostic applications. We understand the critical nature of these tests and are committed to providing a reliable supply chain with competitive prices. If you are looking to purchase PAH for your laboratory or clinical needs, reach out to us to discuss your requirements and benefit from our expertise and product quality.