For professionals in the chemical and pharmaceutical industries, understanding the origin and production of key intermediates is as vital as knowing their applications. 4-Bromo-2,5-difluorobenzoic Acid (CAS: 28314-82-1) is one such compound, a crucial component in many advanced synthesis projects. This article explores its synthesis and provides insights into sourcing it effectively from manufacturers worldwide.

Synthesis Pathways for 4-Bromo-2,5-difluorobenzoic Acid

The preparation of 4-Bromo-2,5-difluorobenzoic Acid typically involves multi-step organic synthesis. A common route begins with 1,4-dibromo-2,5-difluorobenzene. This precursor is treated with a strong base, such as n-butyl lithium, at very low temperatures (-78°C) to achieve lithium-halogen exchange, followed by carboxylation with dry ice (solid carbon dioxide). The resulting crude product is then acidified and extracted, often involving several washing and purification steps, including extraction into sodium bicarbonate and subsequent acidification and extraction into diethyl ether. The final product is usually obtained as a pale yellow solid after drying and concentration. Aspiring buyers who need to purchase this intermediate often inquire about the synthesis processes to ensure quality and reproducibility.

Sourcing Strategies for Chemical Procurement Managers

Procurement managers seeking to buy 4-Bromo-2,5-difluorobenzoic Acid need a strategic approach. China has become a significant hub for the manufacturing of such fine chemicals, offering competitive prices and large-scale production capabilities. When evaluating suppliers, look for those who provide detailed specifications, including a CAS number (28314-82-1), molecular formula (C7H3BrF2O2), molecular weight (237), and a clear description of its appearance (light yellow powder). Ensure they offer a purity of at least 97% and can provide batch-specific Certificates of Analysis.

For critical research applications, obtaining a sample before placing a bulk order is advisable. This allows for in-house quality verification. Furthermore, consider suppliers who offer flexible packaging options, from research quantities (e.g., 25g, 100g) to bulk industrial needs. Engaging with manufacturers who have a strong reputation for quality control and timely delivery will ensure a smooth procurement process, supporting your ongoing research and production demands. Understanding the pricing and supply availability from various manufacturers is a key part of efficient sourcing.