In the realm of organic chemistry and pharmaceutical development, specific molecules serve as foundational elements for innovation. Thiophene-2-carboxylic acid, identified by its CAS number 527-72-0, is one such compound, prized for its reactivity and utility as a key intermediate. This article delves into the chemical characteristics and broad applicability of this important thiophene derivative, highlighting why it's a sought-after product for research and industrial applications. For those looking to buy, understanding its synthesis and properties is crucial.

Understanding Thiophene-2-carboxylic Acid: Properties and Synthesis

Thiophene-2-carboxylic acid presents as a white solid, with a well-defined melting point range of 125-127 °C. Its molecular formula is C5H4O2S, and it has a molar mass of 128.15 g/mol. The compound's structure, featuring a thiophene ring directly attached to a carboxylic acid group at the 2-position, grants it unique electronic and steric properties. Synthesis routes often involve the oxidation of precursors like thiophene-2-carboxaldehyde or 2-acetylthiophene, processes optimized by experienced chemical manufacturers.

Key Reactions and Applications in Pharmaceutical Intermediate Production

The true value of Thiophene-2-carboxylic acid lies in its extensive use as a pharmaceutical intermediate. Its carboxylic acid functionality is readily amenable to esterification, amidation, and other transformations, allowing chemists to build complex molecular architectures. For instance, it serves as a precursor in the synthesis of certain anti-inflammatory drugs and other therapeutic agents. The ability to functionalize the thiophene ring further enhances its utility, making it a versatile component in drug discovery and development pipelines. Sourcing this intermediate from reputable manufacturers ensures the quality required for these sensitive applications.

Exploring the Reactivity: Dianion Formation and Coupling Reactions

Beyond basic functional group transformations, Thiophene-2-carboxylic acid exhibits interesting reactivity. For example, upon treatment with strong bases like Lithium Diisopropylamide (LDA), it can undergo double deprotonation to form a 5-lithio derivative. This lithiated species is a powerful nucleophile and a precursor to a wide array of 5-substituted thiophene derivatives, significantly expanding the synthetic possibilities. Furthermore, Thiophene-2-carboxylic acid has been a substrate of choice in numerous studies involving catalytic decarboxylative coupling reactions and olefinations, demonstrating its importance in modern synthetic methodologies. When you consider purchasing this chemical, understanding these advanced synthetic applications can guide your selection of suppliers.

Procurement Considerations for B2B Buyers

For procurement managers and R&D scientists, sourcing Thiophene-2-carboxylic acid requires careful consideration of supplier reliability, product purity, and price. Manufacturers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., offer this intermediate with guaranteed purity and competitive pricing, often providing bulk quantities. Engaging with a manufacturer that provides detailed technical data, sample availability, and responsive customer service is crucial. By prioritizing these factors, businesses can secure a consistent and high-quality supply of Thiophene-2-carboxylic acid, ensuring the smooth progression of their synthesis projects.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting the chemical and pharmaceutical industries with high-quality intermediates. Our expertise in manufacturing Thiophene-2-carboxylic acid (CAS: 527-72-0) ensures that our clients receive a product that meets stringent purity and performance standards. We invite you to contact us for a quote and explore how our reliable supply chain can benefit your operations.