3-Amino-5-Chlorobenzotrifluoride
- CAS No.69411-05-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Amino-5-Chlorobenzotrifluoride (CAS 69411-05-8), a key fluorinated aromatic intermediate for pharmaceutical and agrochemical synthesis.
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Product Overview
3-Amino-5-Chlorobenzotrifluoride (CAS 69411-05-8) is a high-value fluorinated aromatic amine widely employed as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) and specialty agrochemicals. Its unique molecular architecture—featuring both electron-withdrawing trifluoromethyl and chloro substituents adjacent to an amino group—confers enhanced metabolic stability, lipophilicity, and binding affinity in complex organic molecules, making it indispensable in modern medicinal chemistry workflows.
Specifications
| Molecular Formula | C₇H₅ClF₃N |
|---|---|
| Molecular Weight | 195.57 g/mol |
| Appearance | White powder |
| Purity | ≥98.0% |
| Melting Point | 79–82 °C |
| Boiling Point | 218.2 °C at 760 mmHg |
| Density | 1.425 g/cm³ |
| Flash Point | 85.8 °C |
| Refractive Index | 1.500 |
Industrial Applications
This compound serves primarily as a versatile intermediate in multi-step synthetic routes targeting advanced therapeutics and crop protection agents. Key application areas include:
- Pharmaceutical R&D: Used in the construction of heterocyclic scaffolds for kinase inhibitors, anti-infectives, and CNS-targeted compounds.
- Agrochemical Manufacturing: Functions as a precursor for novel herbicides and fungicides requiring enhanced environmental persistence and target specificity.
- Fluorine Chemistry: Valued for its regioselective reactivity in cross-coupling reactions (e.g., Buchwald-Hartwig amination, Suzuki-Miyaura coupling).
Supplied in standard 25 kg or 200 kg drums with custom packaging available, 3-Amino-5-Chlorobenzotrifluoride must be stored in a tightly sealed container under cool, dry conditions to maintain stability and prevent moisture absorption.
