5-Benzyl L-glutamate N-carboxyanhydride

Product Overview

5-Benzyl L-glutamate N-carboxyanhydride, commonly recognized by its CAS registry number 3190-71-4, stands as a critical specialized intermediate within the pharmaceutical manufacturing sector. This protected amino acid derivative serves as an essential monomer for the ring-opening polymerization processes required to synthesize complex polypeptides. Our facility produces this compound under strict Good Manufacturing Practice guidelines, ensuring consistent quality for downstream pharmaceutical applications, particularly in the production of immunomodulatory agents such as Glatiramer acetate.

Chemical Properties and Specifications

Understanding the physicochemical characteristics of this N-carboxyanhydride monomer is vital for process chemists. The compound features a benzyl protecting group on the gamma-carboxyl function of L-glutamic acid, which prevents unwanted side reactions during polymerization. We maintain rigorous control over optical rotation and moisture content to guarantee reactivity and stereochemical integrity. The compound appears as a white to off-white crystalline powder, indicating high levels of purity. Stability is maintained through careful packaging that excludes moisture, as NCAs are sensitive to hydrolysis which can degrade the monomer before use. The following table outlines the key technical specifications for our standard commercial grade:

Industrial Applications

Beyond its primary use in Glatiramer acetate production, this intermediate is utilized in research and development for novel drug delivery systems. Biodegradable polymers derived from glutamic acid are gaining traction in targeted therapy applications. The high assay percentage of our material ensures minimal initiation failures during ring-opening polymerization. Process chemists rely on our consistent batch-to-batch quality to validate their synthesis routes without needing extensive re-optimization. This reliability accelerates the timeline from laboratory scale to commercial manufacturing.

Quality Assurance and Storage

Quality assurance is the cornerstone of our operation. Every production lot undergoes comprehensive analysis using High-Performance Liquid Chromatography to verify assay purity above 98.0%. Specific rotation tests confirm the L-enantiomeric excess, ensuring no racemization has occurred during synthesis. Moisture content is kept below 1.0% to preserve reactivity. We provide a detailed Certificate of Analysis with each shipment, documenting all critical quality attributes. Our facilities adhere to strict safety and environmental standards, ensuring sustainable production practices. Proper storage is essential to maintain product integrity. We recommend keeping the material in a cool, ventilated area away from direct sunlight and humidity. Standard packaging includes 25 kg fiber drums with inner polyethylene liners, but we offer custom packaging solutions to meet specific logistical needs. Our global supply chain ensures timely delivery to manufacturers worldwide.