6-Chloro-4-iodopyridin-3-ol
- CAS No.877133-58-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity heterocyclic building block designed for advanced pharmaceutical synthesis and cross-coupling reactions.
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Product Overview
6-Chloro-4-iodopyridin-3-ol is a highly specialized heterocyclic compound that serves as a critical building block in modern organic synthesis. Characterized by its unique substitution pattern featuring both chloro and iodo functional groups on a pyridinol core, this molecule offers exceptional versatility for medicinal chemistry applications. The presence of multiple halogen sites enables diverse transformation pathways, making it an invaluable asset for researchers and industrial manufacturers focused on developing novel pharmaceutical agents.
Our facility produces this intermediate under strict quality control protocols to ensure consistent performance in downstream reactions. The compound is supplied with comprehensive documentation, including certificates of analysis, to support regulatory compliance and research integrity. Whether utilized for lead optimization or large-scale process development, this material provides the reliability required for high-stakes chemical synthesis.
Key Specifications
The following table outlines the critical physical and chemical parameters verified during our quality assurance process. Each batch undergoes rigorous testing to confirm compliance with established factory standards.
| Parameter | Specification |
|---|---|
| CAS Number | 877133-58-9 |
| Molecular Formula | C5H3ClINO |
| Molecular Weight | 255.44 g/mol |
| Appearance | Gray to brown solid |
| Assay (Purity) | ≥95.0% |
| Density | 2.219 g/cm3 |
| Boiling Point | 332.821°C at 760 mmHg |
| Flash Point | 155.085°C |
| Refractive Index | 1.691 |
Industrial Applications
This halogenated pyridine derivative is predominantly employed in the construction of complex molecular architectures. The iodine substituent serves as an excellent handle for palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Sonogashira couplings, allowing for the precise introduction of aryl or alkynyl groups. Simultaneously, the chloro group offers orthogonal reactivity, enabling sequential functionalization strategies that are essential for building multi-substituted heterocyclic systems.
In the pharmaceutical sector, this intermediate is frequently utilized in the synthesis of kinase inhibitors and other targeted therapeutics. Its structural framework provides a robust scaffold for structure-activity relationship studies. Additionally, the hydroxyl group on the pyridine ring can be further derivatized to enhance solubility or binding affinity, offering chemists significant flexibility in drug design protocols.
Quality Assurance and Handling
- Manufactured in ISO-compliant facilities with full traceability.
- Every batch is tested using HPLC and NMR to verify structural integrity.
- Packaged in moisture-resistant containers to maintain stability during transit.
- Supported by technical teams for synthesis route optimization.
Proper handling procedures should be followed to ensure safety and material integrity. The compound should be stored in a cool, dry place away from direct sunlight and incompatible oxidizing agents. When handled correctly, this intermediate maintains its specified purity profile over extended storage periods, ensuring consistent results in your production cycles.
