N-Ethyl-N-(o-tolyl)butenamide (Crotamiton)
- CAS No.483-63-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Crotamiton (CAS: 483-63-6) is a critical intermediate for Active Pharmaceutical Ingredient (API) synthesis and life sciences research. Our company delivers mature commercial-scale production capabilities and reliable supply, backed by comprehensive custom contract manufacturing services.
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Basic Chemical Information
Product Chinese Name: Crotamiton (N-Ethyl-N-(o-tolyl)butenamide)
Product English Name: Crotamiton / N-Ethyl-o-crotonotoluidide
CAS No.: 483-63-6
Chinese Synonyms: N-Ethyl-o-crotonoyltoluidine, N-Ethyl-N-(2-methylphenyl)-2-butenamide, Eurax, Crotamit
English Synonyms: (2E)-N-ethyl-N-(2-methylphenyl)but-2-enamide, Eurax, Euraxil, Crotamitex, Veteusan
Physical & Chemical Properties & Process Parameters
| Property Parameter | Specification Data |
|---|---|
| Molecular Formula | C13H17NO |
| Molecular Weight | 203.28 |
| Melting Point | Below 25°C (typically liquid at room temperature) |
| Boiling Point | 153-155°C (at 13 mmHg / 1.73 kPa vacuum) |
| Relative Density | 1.008-1.014 g/cm3 (Standard reference value at 25°C: 1.008-1.011) |
| Refractive Index | nD20 1.540-1.542 |
| Flash Point | 115.5°C |
| Solubility | Highly soluble in DMF; soluble in ethanol, methanol, diethyl ether, and chloroform; slightly soluble in glacial acetic acid; low solubility in water (~1:500) |
| Stability | Stable at room temperature and pressure. Light-sensitive; store in a tightly sealed container away from light. |
Product Specifications & Quality Control
| Test Item | Quality Standard (Pharma Grade / Research Grade) |
|---|---|
| Appearance | Colorless to pale yellow slightly viscous oil-like liquid |
| Purity / Assay (GC) | ≥99.0% (primarily composed of the trans isomer) |
| Residue on Ignition | ≤0.1% |
| Chlorides (as Cl) | ≤0.01% |
| Free Amine | ≤2.5 mg/g |
| Water Content (KF) | ≤0.5% |
Core Applications & Downstream Value
Core Use in Pharmaceutical API: Crotamiton is a highly effective topical antipruritic and anti-parasitic agent. Clinically, it is primarily used to treat scabies and pruritus caused by various allergic skin conditions, eczema, neurodermatitis, etc. It works by blocking histamine- and serotonin-induced itch reflexes, and is commonly formulated into 10% creams or lotions. For international brands like Eurax and Eurax series formulations, our product serves as a seamless drop-in replacement, fully matching their pharmacokinetics and physicochemical parameters to meet the strict input requirements of high-end formulations.
Life Sciences & Biochemical Research: In pharmacological and molecular biology studies, crotamiton has been identified as a TRPV4 (Transient Receptor Potential Vanilloid 4) ion channel inhibitor. It can be utilized in in vitro cell assays or animal models to inhibit TRPV4 currents and study agonist-induced pruritic behaviors, providing high-purity reagent support for neuroimmunology research.
Cosmetics & Daily Chemical Additives: Leveraging its excellent antipruritic and soothing properties, it can be used as an auxiliary additive for anti-itch and anti-allergy effects in compliant specialty cosmetics or topical soothing lotions, significantly enhancing the sensory profile and efficacy experience of end products.
Compliance Statement & Usage Guidelines
This product is intended solely for industrial synthesis, scientific research, or foreign trade export. Direct use in human or veterinary medicine is strictly prohibited. Downstream customers must strictly comply with GMP standards and cosmetic/pharmaceutical registration regulations in their target markets during formulation development or compounding processes.
Source Manufacturer & Proprietary Continuous Flow Technology Advantages
As a direct source manufacturer of Crotamiton, NINGBO INNO PHARMCHEM CO.,LTD. leverages independently developed and engineered pipeline-style continuous flow reactors to completely overcome the limitations of traditional batch kettle processes. This proprietary microchannel continuous flow technology enables precise temperature control and highly efficient mass transfer for liquid-in/liquid-out reactions, fundamentally ensuring batch-to-batch consistency and production safety. We reject opaque operations; instead, we provide a transparent quality control system and pilot-scale upscaling capabilities, offering end-to-end support for downstream clients ranging from gram-level R&D to metric-ton commercial delivery. We sincerely invite global trading companies, formulation terminals, and academic/research institutions to establish long-term strategic partnerships to jointly expand the market for pharmaceutical/agrochemical intermediates and specialty chemicals.
