Bromomethylcyclopropane
- CAS No.7051-34-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity bromomethylcyclopropane (CAS: 7051-34-5) is a critical intermediate and raw material for API and fine chemical synthesis. Our company provides proven large-scale manufacturing capabilities alongside customized contract manufacturing (OEM) services.
Request Bulk PricingProduct Technical Details
Basic Chemical Information
Chinese Name: Bromomethylcyclopropane
English Name: Bromomethylcyclopropane
CAS No.: 7051-34-5
Chinese Synonyms: Cyclopropylmethyl bromide, (Bromomethyl)cyclopropane, 1-(Bromomethyl)cyclopropane, Bromocyclopropylmethane
English Synonyms: Cyclopropylmethyl bromide, (Bromomethyl)cyclopropane, 1-(Bromomethyl)cyclopropane, Cyclopropanemethyl bromide
Physical & Chemical Properties
Molecular Formula: C4H7Br
Molecular Weight: 135.00 g/mol
Boiling Point: 105–107 °C (at atmospheric pressure)
Relative Density: d²⁵ = 1.392
Refractive Index: nD²⁰ = 1.472–1.476 (typical: 1.475)
Flash Point: 41 °C (closed cup)
Solubility: Insoluble in water; freely soluble in chloroform, methanol, diethyl ether, dichloromethane, and most common organic solvents.
Stability: Relatively stable at ambient temperature and pressure, but classified as a flammable liquid. Due to its strained three-membered ring, it readily undergoes ring-opening rearrangement/isomerization upon heating or in the presence of specific catalysts. It is also photosensitive. Store in a cool, dark place in tightly sealed containers under nitrogen atmosphere.
Product Specifications
| Parameter | Specification |
|---|---|
| Appearance | Colorless to slightly yellow transparent liquid |
| Purity (GC) | ≥99.0% |
| Water Content (KF) | ≤0.5% |
Application Fields & Process Compatibility
Pharmaceutical API Intermediates (Core Application): Bromomethylcyclopropane is a critical cyclopropylmethylating agent in modern drug synthesis. Widely used in the pharmaceutical industry to construct side chains for key CNS drugs, analgesics, and opioid receptor antagonists such as naltrexone, nalmefene, and buprenorphine. For naltrexone intermediate and buprenorphine side-chain synthetic routes, our product serves as a seamless drop-in replacement, with batch-to-batch consistency strictly aligned with top-tier international standards.
Agrochemical & Fine Chemical Synthesis: Leveraging its highly reactive bromo site, it is utilized to synthesize molecular scaffolds for high-bioactivity insecticides and herbicides. In fundamental organic synthesis, it frequently participates in transition-metal-catalyzed cross-coupling reactions and efficiently enables N/O/S-alkylation of various amines, alcohols, and thiols.
Specialty Electronics & New Materials: Its unique strained cyclopropane ring serves as a key functionalizing reagent for terminal modification in specialty polymer monomers, fluorinated liquid crystal materials, and optoelectronic compounds.
Source Manufacturer & Proprietary Continuous Flow Technology Advantages
As a direct source manufacturer of bromomethylcyclopropane, NINGBO INNO PHARMCHEM CO.,LTD. operates proprietary inline continuous flow reactors designed in-house. This process eliminates the safety hazards associated with traditional batch reactors, enabling precise liquid-in/liquid-out processing and temperature control to guarantee exceptional batch stability and inherent safety. We are committed to building long-term strategic partnerships with domestic and international trading companies, end-use pharmaceutical manufacturers, and fine chemical users, offering one-stop custom contract manufacturing from gram-scale pilot runs to ton-level commercial delivery. Core process parameters are strictly confidential. COAs and samples are available upon request for process validation.
