Industrial Purity Specifications for 2-Bromo-6-Fluoropyridine (CAS 144100-07-2)
- High Purity Standards: Guaranteed ≥98.0% purity via GC/HPLC analysis for critical synthesis.
- Bulk Procurement: Scalable manufacturing process ensuring consistent supply chains.
- Comprehensive Documentation: Full COA, SDS, and COO provided for regulatory compliance.
In the realm of advanced organic synthesis, the reliability of heterocyclic building blocks is paramount. 2-Bromo-6-fluoropyridine (CAS: 144100-07-2) stands as a critical intermediate for the development of pharmaceuticals, agrochemicals, and functional materials. As a global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. understands that the efficacy of downstream reactions depends heavily on the industrial purity of the starting material. This technical overview details the specifications, analytical methods, and supply chain considerations necessary for procuring this compound at scale.
Technical Specifications and Physical Properties
Understanding the physicochemical properties of 2-bromo-6-fluoro-pyridine is essential for safe handling and process integration. The compound is a halogenated pyridine derivative where the specific positioning of the bromo and fluoro substituents dictates its reactivity in nucleophilic aromatic substitution reactions. Below are the standard technical specifications expected for industrial-grade material.
| Property | Specification |
|---|---|
| Chemical Name | 2-Bromo-6-fluoropyridine |
| CAS Number | 144100-07-2 |
| Molecular Formula | C5H3BrFN |
| Molecular Weight | 175.99 g/mol |
| Melting Point | 30°C to 34°C |
| Purity (GC Area %) | ≥ 98.0% (Standard), ≥ 99.0% (Custom) |
| UN Number | UN2811 (Toxic solids, organic, n.o.s.) |
Analytical Methods for Purity Verification
Ensuring the quality of heterocyclic intermediates requires rigorous analytical validation. While standard market offerings may hover around 97% purity, industrial applications often demand tighter controls to minimize side reactions. The primary method for assessing industrial purity is Gas Chromatography (GC) coupled with Flame Ionization Detection (FID) or Mass Spectrometry (MS). High-Performance Liquid Chromatography (HPLC) is also utilized for specific polarity assessments.
A critical aspect of quality control is the identification of isomeric impurities. During the manufacturing process, there is a risk of forming structural isomers such as 2-Fluoro-6-bromopyridine (which is technically the same compound but naming conventions vary) or regioisomers like 2-Fluor-5-brompyridin. These impurities can significantly alter reaction kinetics and yield in downstream coupling reactions. Our quality assurance protocols specifically screen for these isomers to ensure the material performs predictably in cross-coupling catalysis.
Every batch shipped is accompanied by a Certificate of Analysis (COA). This document details the specific batch number, manufacturing date, and actual test results against the specification limits. For regulatory compliance in pharmaceutical supply chains, the COA is a non-negotiable document that verifies the identity and strength of the chemical component.
Synthesis Routes and Downstream Applications
The utility of this fluorinated pyridine lies in its dual functionality. The carbon-bromine bond is susceptible to palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig aminations. Meanwhile, the carbon-fluorine bond offers stability but can be activated under specific conditions for nucleophilic aromatic substitution. This dual reactivity makes it a versatile scaffold in medicinal chemistry.
When sourcing high-purity 2-Bromo-6-fluoropyridine, buyers should consider the intended synthesis route. In pharmaceutical development, this compound serves as a key intermediate for synthesizing APIs targeting neurological and infectious diseases. The presence of trace metal catalysts or moisture can degrade the quality of the final active ingredient, necessitating high-quality starting materials.
Beyond pharmaceuticals, the compound is utilized in the formulation of agrochemicals. It acts as a building block for herbicides and fungicides, enhancing crop protection products. In material science, the unique chemical properties of the pyridine ring improve the durability and performance of advanced polymers and coatings. Additionally, research in organic chemistry frequently employs this molecule for synthesizing complex organic molecules, aiding in the exploration of new chemical reactions and fluorescent probes for biological imaging.
Quality Assurance and Regulatory Documentation
Procuring chemicals for industrial use requires more than just the product; it requires a suite of documentation to ensure safety and compliance. NINGBO INNO PHARMCHEM CO.,LTD. provides a comprehensive package for every order. This includes Safety Data Sheets (SDS) which provide comprehensive safety information on handling, storage, and disposal of the product. Proper storage is critical; the material should be kept in a cool, dry place away from incompatible materials due to its classification under UN2811.
Furthermore, Product Specifications (PS) provide a comprehensive breakdown of the product's properties, including chemical composition, physical state, purity, and storage requirements. For international trade, Certificates of Origin (COO) are essential. This COO confirms the country where the product was manufactured and details the materials and components used. This certificate may be required for customs, trade, and regulatory compliance, ensuring smooth logistics across borders.
Storage and Stability Considerations
To maintain the specified industrial purity over time, proper storage conditions are vital. The compound should be stored under inert gas (nitrogen or argon) if long-term storage is required, as exposure to moisture can lead to hydrolysis of the halogenated positions. Containers must be tightly closed and labeled with the appropriate hazard warnings. Regular inventory rotation ensures that the material used in production meets the initial specifications outlined in the COA.
Commercial Availability and Bulk Procurement
For research and development labs, small quantities are often sufficient. However, scaling to commercial production requires a reliable supply chain capable of delivering metric tons without quality deviation. As a leading global manufacturer, we offer scalable production capacities that align with client demand. Bulk pricing structures are available for long-term contracts, ensuring cost-efficiency for large-scale synthesis projects.
Transparency in the manufacturing process allows clients to audit supply chains effectively. We prioritize consistency in batch-to-bquality, minimizing the need for re-validation of downstream processes. Whether for academic research or industrial production, securing a stable source of high-quality intermediates is the foundation of successful chemical development.
In conclusion, the selection of 2-Bromo-6-fluoropyridine should be driven by verified purity data, robust analytical support, and reliable logistics. By partnering with NINGBO INNO PHARMCHEM CO.,LTD., clients gain access to premium intermediates backed by technical expertise and comprehensive regulatory documentation.