2-Bromo-6-fluoropyridine
- CAS No.144100-07-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Bromo-6-fluoropyridine (CAS 144100-07-2), a key building block for pharmaceutical intermediates. Ideal for advanced organic synthesis and R&D applications.
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Product Overview
2-Bromo-6-fluoropyridine is a versatile halogenated heterocyclic compound widely employed as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. With its dual functionality—featuring both bromo and fluoro substituents at strategic positions on the pyridine ring—it serves as a valuable scaffold for cross-coupling reactions, nucleophilic substitutions, and other transformations central to modern medicinal chemistry.
Specifications
| Molecular Formula | C₅H₃BrFN |
|---|---|
| Molecular Weight | 175.99 g/mol |
| CAS Number | 144100-07-2 |
| Appearance | White crystalline powder |
| Purity | ≥98.0% (by GC or HPLC) |
| Density | 1.7 ± 0.1 g/cm³ |
| Melting Point | 30–32 °C |
| Boiling Point | 200.2 ± 20.0 °C at 760 mmHg |
| Flash Point | 74.9 ± 21.8 °C |
| Refractive Index | 1.534 |
Industrial Applications
This compound is primarily utilized in the pharmaceutical industry as a synthetic intermediate. Its structural features enable efficient construction of complex molecules targeting neurological, oncological, and anti-infective therapeutic areas. It is also applicable in agrochemical research and specialty materials development where fluorinated pyridine motifs are required.
- Enables Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions
- Suitable for late-stage functionalization in multi-step syntheses
- Compatible with standard handling protocols for moisture-sensitive organohalides
Stored in tightly sealed containers under cool, dry conditions, 2-Bromo-6-fluoropyridine maintains stability during transport and long-term storage. Supplied in 25 kg drums for industrial-scale procurement.
