1-Bromo-2-Fluoro-4-Iodobenzene Bulk Price Global Manufacturer 2026
- Technical Specifications: CAS 136434-77-0, Melting Point 34-38°C, Boiling Point 80°C at 2.5 mmHg.
- Procurement Insight: Bulk pricing tiers fluctuate based on iodine raw material costs and purification complexity.
- Quality Assurance: Verified suppliers provide full COA documentation and guarantee >97% GC purity for OLED applications.
The demand for halogenated aromatic intermediates continues to surge within the pharmaceutical and organic light-emitting diode (OLED) sectors. Among these, 1-Bromo-2-fluoro-4-iodobenzene (CAS 136434-77-0) stands out as a critical building block for cross-coupling reactions. As we approach 2026, procurement managers must navigate volatile raw material costs and stringent quality requirements. This analysis provides a technical deep dive into the manufacturing process, pricing structures, and supply chain strategies necessary for securing reliable bulk supply.
From a synthetic chemistry perspective, this tri-halogenated benzene derivative offers unique reactivity profiles due to the differential leaving group abilities of iodine, bromine, and fluorine. The iodine atom typically facilitates oxidative addition in palladium-catalyzed reactions, while the bromine and fluorine atoms remain intact for subsequent functionalization. Maintaining industrial purity is paramount, as trace impurities can poison catalysts or alter emission spectra in final OLED materials.
Wholesale Pricing Tiers for 1-Bromo-2-fluoro-4-iodobenzene
Pricing for halogenated intermediates is heavily influenced by the cost of elemental iodine and the complexity of the purification process. Market data indicates significant variance between laboratory-scale packs and industrial drum quantities. Small-scale packaging (5g to 25g) often commands a premium due to handling and packaging overheads, with prices historically ranging significantly higher per gram compared to bulk orders.
For commercial-scale procurement, the bulk price is determined by several factors including order volume, purity specifications, and lead times. Manufacturers typically offer tiered pricing structures. Orders exceeding 100 kilograms often benefit from substantial discounts compared to kilogram-scale purchases. However, buyers must account for the volatility of halogen raw materials. The synthesis often involves halogen exchange reactions or direct iodination of bromofluorobenzene precursors, processes that require careful temperature control to prevent poly-iodination or debromination.
When evaluating quotes, procurement teams should request a breakdown of costs related to purification. Achieving >97% purity via gas chromatography (GC) often requires vacuum distillation or recrystallization, which adds to the production cost. A reliable global manufacturer will transparently discuss these processing steps. For example, vacuum distillation at low pressures (approximately 2.5 mmHg) is standard to isolate the product given its boiling point of 80°C under those conditions. Failure to properly distill can result in residual starting materials that compromise downstream synthesis.
Identifying Verified Global Manufacturer Partners
Selecting the right supply partner is critical for maintaining production continuity. The chemical market contains numerous traders, but few possess the actual manufacturing capability to produce complex halogenated aromatics consistently. Verification should begin with a review of the facility's quality control protocols. A legitimate producer will provide a comprehensive Certificate of Analysis (COA) with every batch, detailing purity levels, melting point ranges (34-38°C), and impurity profiles.
Buyers should prioritize partners who demonstrate expertise in the specific synthesis route required for this molecule. The production of 4-bromo-3-fluoro-1-iodobenzene, a common synonym for this compound, requires specialized corrosion-resistant equipment due to the presence of halogens. During the vetting process, request information on their batch consistency and capacity to scale from pilot runs to multi-ton production.
When sourcing high-purity 1-bromo-2-fluro-4-iodobenzene, buyers should ensure the supplier has robust safety protocols in place. This compound is light-sensitive and should be stored in sealed, dark containers at room temperature to prevent degradation. NINGBO INNO PHARMCHEM CO.,LTD. has established itself as a premier provider in this sector, offering technical support and consistent supply chains for complex intermediates. Partnering with an entity that understands the nuances of halogen stability ensures that the material arrives with the specified physicochemical properties intact.
Additionally, verify the supplier's regulatory compliance. Export documentation, safety data sheets (SDS), and transport classifications (often classified as irritants or light-sensitive solids) must be accurate to avoid customs delays. A top-tier manufacturer will handle all hazardous material logistics compliantly.
2026 Market Forecast and Bulk Procurement Strategies
Looking toward 2026, the market for fluorinated and iodinated benzene derivatives is projected to grow, driven by expansion in the OLED display industry and novel pharmaceutical pipelines. This increased demand may tighten supply for high-grade intermediates. Procurement strategies should shift from just-in-time purchasing to forward contracting for critical materials.
To mitigate risk, companies should consider establishing long-term agreements with manufacturers who can guarantee capacity. Spot pricing may fluctuate based on geopolitical factors affecting raw material transport. Securing a supply line with a manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to stable production schedules and priority allocation during peak demand periods.
Technical due diligence remains the cornerstone of successful procurement. Buyers should specify tolerance levels for isomers such as 3-fluoro-4-bromo-iodobenzene variants, ensuring the regiochemistry matches their synthetic needs. The presence of incorrect isomers can drastically reduce yields in subsequent coupling steps. Furthermore, confirming the physical form is essential; this product typically presents as a crystalline low melting solid or pale brown liquid depending on temperature, with a density estimated around 2.2691 g/cm³.
In conclusion, securing a reliable supply of 1-Bromo-2-Fluoro-4-Iodobenzene requires a balance of technical understanding and commercial acumen. By focusing on verified manufacturing capabilities, understanding purification costs, and forecasting market trends, organizations can optimize their supply chains for the coming years.
Technical Specifications Overview
| Property | Specification |
|---|---|
| CAS Number | 136434-77-0 |
| Molecular Formula | C6H3BrFI |
| Molecular Weight | 300.89 g/mol |
| Melting Point | 34-38 °C |
| Boiling Point | 80°C at 2.5 mmHg |
| Density | ~2.2691 g/cm³ |
| Purity (GC) | >97.0% |
| Storage | Dark, Sealed, Room Temperature |
Final verification of any shipment should involve independent testing upon receipt. Confirming the COA data against internal QC standards ensures that the 4-bromo-3-fluoro-iodobenzene received meets the rigorous demands of modern synthetic applications. By adhering to these procurement guidelines, chemical buyers can secure high-quality intermediates essential for innovation in 2026 and beyond.