5-Trifluoromethyl-3-Chloropyridine Industrial Purity Coa Specifications
- High Purity Standards: Industrial grades typically exceed 98.0% purity via GC analysis, ensuring minimal downstream contamination.
- Critical Physical Data: Boiling point approx. 144°C and melting point 131.5°C require specific storage conditions to maintain stability.
- Bulk Procurement: Scalable manufacturing processes support ton-level supply for pharmaceutical and agrochemical applications.
In the realm of advanced organic synthesis, the reliability of heterocyclic building blocks is paramount for process efficiency. 3-Chloro-5-(trifluoromethyl)pyridine (CAS: 85148-26-1) stands out as a critical Fluorinated pyridine derivative utilized extensively in the development of novel pharmaceuticals and agrochemicals. For process chemists and procurement managers, understanding the nuances of industrial purity and Certificate of Analysis (COA) specifications is essential for mitigating supply chain risks. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. adheres to stringent quality control protocols to deliver consistent batch-to-batch performance for this valuable Organic synthesis intermediate.
Understanding Industrial Purity Standards ≥98.0%
When evaluating suppliers for bulk chemical procurement, the stated purity on a COA is often the first metric assessed. However, industrial purity encompasses more than a single percentage figure. For 3-Chloro-5-(trifluoromethyl)pyridine, standard commercial grades often range between 97% and 99%. Achieving purity levels ≥98.0% typically requires rigorous purification steps, such as fractional distillation or recrystallization, to remove structural isomers and unreacted starting materials.
Impurities in fluorinated pyridines can significantly impact downstream coupling reactions. For instance, the presence of residual halides or moisture can poison catalysts used in cross-coupling methodologies. Therefore, high-quality specifications usually include limits on water content (Karl Fischer titration) and related substances via Gas Chromatography (GC). Buyers should prioritize suppliers who provide detailed chromatograms alongside their COA to verify the absence of closely eluting impurities that could compromise reaction yields.
Interpreting Certificate of Analysis (COA) Data
A comprehensive COA is the backbone of quality assurance in B2B chemical transactions. For CAS 85148-26-1, a robust COA should detail specific analytical methods and acceptance criteria. Key parameters include assay purity, identity confirmation (IR, NMR, or MS), and physical constants. Below is a representative table of technical specifications expected for high-grade material:
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | Colorless to off-white solid/liquid | Visual Inspection |
| Assay (Purity) | ≥ 98.0% | GC Area % |
| Water Content | ≤ 0.5% | Karl Fischer |
| Boiling Point | 144°C | Distillation |
| Melting Point | 131.5 °C | DSC / Capillary |
| Identity | Consistent with Reference Standard | FTIR / 1H NMR |
It is crucial to note that physical forms may vary based on ambient temperature, as the compound transitions between solid and liquid states near room temperature (Melting point 131.5 °C). Proper documentation ensures that the material received matches the technical requirements for your specific synthesis route.
Physical Specifications and Storage Requirements
The physicochemical properties of this Pharmaceutical precursor dictate its handling and storage protocols. With a molecular weight of 181.54 g/mol and a density of approximately 1.416 g/cm³, the material is relatively dense. The refractive index typically falls between 1.4460 and 1.4500, serving as a quick identity check in quality control laboratories.
Safety data indicates that the compound carries GHS hazard classifications including Acute Toxicity and Irritation. Consequently, storage conditions must strictly adhere to safety guidelines. The material should be kept in a dark place, sealed in dry conditions at room temperature to prevent hydrolysis or degradation. Exposure to moisture or incompatible strong oxidizing agents should be avoided. Proper ventilation is required during handling to mitigate respiratory risks associated with volatile organic compounds.
Synthesis Routes and Bulk Procurement
From a manufacturing perspective, the production of 3-Chloro-5-(trifluoromethyl)pyridine often involves selective halogenation or reduction strategies. A common synthetic approach utilizes 2,3-dichloro-5-trifluoromethylpyridine as a starting material, employing selective reduction methods to remove the specific chloro substituent while retaining the trifluoromethyl group. Optimizing these reaction conditions is vital for maximizing yield and minimizing waste, which directly influences the bulk price and availability of the final product.
For research and development teams scaling up processes, securing a reliable supply chain is critical. When sourcing high-purity 3-Chloro-5-(trifluoromethyl)pyridine, buyers should evaluate the manufacturer's capacity for custom synthesis and scale-up support. NINGBO INNO PHARMCHEM CO.,LTD. offers robust manufacturing capabilities designed to meet the demands of large-scale Agrochemical intermediate production as well as specialized pharmaceutical campaigns.
In conclusion, selecting the right supplier for CAS 85148-26-1 involves a deep dive into technical specifications, safety compliance, and manufacturing reliability. By prioritizing verified COA data and established industrial purity standards, procurement officers can ensure seamless integration of this heterocyclic building block into their production workflows. Partnering with an experienced chemical supplier guarantees not only product quality but also the technical support necessary for successful process optimization.