3-Chloro-5-(trifluoromethyl)pyridine
- CAS No.85148-26-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity organic synthesis intermediate used in pharmaceutical and agrochemical manufacturing. Available in bulk with strict quality control and global shipping.
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Product Overview
3-Chloro-5-(trifluoromethyl)pyridine is a highly valued fluorinated heterocyclic compound widely utilized in modern organic synthesis and fine chemical manufacturing. As a key building block, this pyridine derivative features a unique structural combination of a chloro substituent and a trifluoromethyl group on the pyridine ring. This specific arrangement enhances the lipophilicity and metabolic stability of downstream molecules, making it an essential component in the development of advanced pharmaceutical agents and agrochemical formulations. Our company specializes in the production of this high-quality intermediate, ensuring consistent supply for research and industrial scale applications worldwide.
The presence of the trifluoromethyl moiety significantly influences the electronic properties of the pyridine ring, facilitating various nucleophilic substitution reactions. Chemists and process engineers favor this compound for its reactivity profile and compatibility with diverse synthetic routes. Whether used in cross-coupling reactions or as a precursor for more complex heterocycles, 3-Chloro-5-(trifluoromethyl)pyridine delivers reliable performance in laboratory and manufacturing environments. The stability of the chloro-pyridine structure allows for versatile functionalization, supporting innovation in medicinal chemistry and material science sectors.
Technical Specifications
We adhere to strict quality control protocols to guarantee the purity and physical characteristics of every batch. The following table outlines the standard specifications for our commercial grade material. Custom specifications may be available upon request for specific project requirements, ensuring flexibility for diverse industrial needs.
| Parameter | Specification |
|---|---|
| Chemical Name | 3-Chloro-5-(trifluoromethyl)pyridine |
| CAS Number | 85148-26-1 |
| Molecular Formula | C6H3ClF3N |
| Molecular Weight | 181.543 g/mol |
| Appearance | Off-white crystalline powder |
| Assay (Purity) | ≥98.0% |
| Boiling Point | 146.0±35.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 42.1±25.9 °C |
| Refractive Index | 1.447 |
Industrial Applications
This chemical intermediate serves multiple roles across various sectors of the fine chemical industry. Its primary utility lies in the construction of biologically active molecules where fluorine incorporation is critical for enhancing bioavailability and binding affinity. The compound is particularly valued in scenarios requiring robust chemical stability under varying processing conditions.
- Pharmaceutical Intermediates: Used in the synthesis of kinase inhibitors and receptor modulators where metabolic stability is required for drug candidates.
- Agrochemical Development: Acts as a core structure for novel herbicides and pesticides designed for improved environmental profiles and efficacy.
- Material Science: Employed in the creation of specialized polymers and liquid crystals requiring fluorinated components for performance enhancement.
- Research and Development: Essential reagent for academic and industrial laboratories exploring heterocyclic chemistry and new synthetic methodologies.
Quality Assurance and Storage
Quality is paramount in our manufacturing process. Each production batch undergoes rigorous testing using advanced analytical techniques such as HPLC and GC-MS to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment to ensure transparency and compliance with international standards. Our facility maintains strict environmental controls to prevent contamination during production and packaging phases.
For optimal stability, 3-Chloro-5-(trifluoromethyl)pyridine should be stored in a cool, ventilated place away from direct sunlight and moisture. Proper personal protective equipment (PPE) is recommended during handling to ensure safety. The standard packaging is 25 kg per drum, but we offer flexible packaging solutions to meet specific logistical needs. Our global supply chain ensures timely delivery while maintaining product integrity throughout transit. Contact our sales team for bulk pricing, technical data sheets, or custom synthesis inquiries to support your project requirements.
