6-Bromo-5-Fluoropicolinic Acid Bulk Price Global Manufacturer 2026
- Market Stability: 2026 forecasts indicate stabilized pricing for halogenated pyridines due to optimized synthesis routes.
- Purity Standards: Industrial grade availability exceeds 98% purity with comprehensive COA documentation.
- Supply Chain: Lead times for bulk procurement range from 2 to 4 weeks depending on customization requirements.
The demand for specialized heterocyclic compounds continues to surge within the pharmaceutical and agrochemical sectors. Among these, 6-Bromo-5-fluoropicolinic acid (CAS: 1052714-46-1) stands out as a critical intermediate for developing next-generation therapeutics. As a premier global manufacturer, understanding the technical specifications and commercial dynamics of this compound is essential for procurement managers and process chemists alike. This analysis provides a detailed overview of manufacturing capabilities, pricing structures, and quality assurance protocols expected to define the market in 2026.
Technical Specifications and Synthesis Route
The production of high-quality 6-Bromo-5-fluoropicolinic acid requires precise control over halogenation and oxidation steps. The molecular formula C6H3BrFNO2 and a molecular weight of 220.00 g/mol dictate specific handling parameters during synthesis. Industrial processes typically involve the oxidation of corresponding picoline derivatives or direct carboxylation of halogenated pyridine precursors. Achieving high reaction yields while maintaining the integrity of the fluorine and bromine substituents is the primary challenge in the manufacturing process.
Advanced facilities utilize controlled temperature regimes and specific catalytic systems to minimize byproduct formation. The resulting industrial purity often surpasses 98%, suitable for direct use in multi-step organic synthesis. When sourcing high-purity 6-bromo-5-fluoropyridine-2-carboxylic acid, buyers should verify the presence of residual solvents and heavy metals through HPLC and ICP-MS analysis. NINGBO INNO PHARMCHEM CO.,LTD. employs rigorous quality control measures to ensure every batch meets these stringent chemical standards.
Physical and Chemical Properties
Understanding the physical properties is vital for storage and handling within a production facility. The compound exhibits a boiling point of approximately 331.3±42.0°C at 760 mmHg. Proper storage at room temperature in sealed containers prevents hydrolysis and degradation. Below is a comparison of standard technical parameters against typical market offerings.
| Parameter | Standard Specification | Industrial Grade Target |
|---|---|---|
| CAS Number | 1052714-46-1 | 1052714-46-1 |
| Molecular Formula | C6H3BrFNO2 | C6H3BrFNO2 |
| Molecular Weight | 220.00 g/mol | 220.00 g/mol |
| Purity (HPLC) | > 98.0% | > 99.0% |
| Appearance | Off-white to Light Yellow Solid | White Crystalline Powder |
| Lead Time (Bulk) | 2-4 Weeks | Negotiable |
2026 Market Pricing Trends for Halogenated Pyridines
Pricing for fluorinated building blocks is influenced by raw material costs, energy consumption, and regulatory compliance. Historical data suggests that small-scale research quantities command a premium, with prices significantly higher per gram compared to metric ton contracts. For instance, laboratory-scale packages often range significantly higher than bulk industrial rates. In 2026, the bulk price is expected to stabilize as supply chains mature and synthesis efficiencies improve.
Procurement strategies should account for volume tiers. While small quantities (milligrams to grams) are suitable for R&D, commercial production requires kilogram to ton-scale sourcing. The cost per unit decreases substantially with volume commitments. Factors such as custom packaging, specific particle size distribution, and expedited shipping can affect the final landed cost. Buyers are advised to secure long-term contracts to mitigate volatility in the pharmaceutical raw materials sector.
Quality Assurance and Documentation
Reliable supply chains depend on transparent documentation. A comprehensive Certificate of Analysis (COA) is non-negotiable for GMP-compliant manufacturing. This document should detail assay results, impurity profiles, and residual solvent analysis. NINGBO INNO PHARMCHEM CO.,LTD. ensures that all shipments are accompanied by full technical dossiers, including NMR and LC-MS spectra upon request. This level of quality assurance minimizes risk during downstream processing and regulatory filings.
Furthermore, the classification of this compound within the broader category of heterocyclic compounds requires adherence to specific safety protocols. Handling procedures must account for potential irritancy and environmental hazards. Proper training for staff handling these intermediates ensures safety and maintains product integrity throughout the supply chain.
Global Supply Chain and Lead Times
Logistics play a crucial role in the availability of specialized intermediates. While standard lead times for stock items may be short, custom synthesis projects require careful planning. A typical synthesis route for bespoke batches involves a feasibility study followed by pilot scale-up. This process ensures that the custom synthesis meets the exact specifications required by the client's process chemistry team.
Global distribution networks facilitate timely delivery to major pharmaceutical hubs. However, regional regulations regarding the import of chemical intermediates can impact transit times. Procurement officers should verify import licenses and hazardous material shipping classifications well in advance. By partnering with a dedicated manufacturer, clients can navigate these complexities more effectively, ensuring consistent supply for continuous manufacturing operations.
Conclusion and Procurement Strategy
The market for 6-Bromo-5-fluoropicolinic acid is poised for steady growth driven by innovation in medicinal chemistry. Securing a reliable supply of this key intermediate is critical for maintaining production schedules and managing costs. With a focus on high purity, technical support, and competitive bulk pricing, manufacturers are ready to support large-scale commercialization efforts.
For organizations seeking a strategic partner for 6-Bromo-5-fluoropicolinic acid procurement, evaluating technical capability and supply chain resilience is paramount. By prioritizing vendors who offer transparent pricing models and robust quality systems, companies can safeguard their production pipelines against market fluctuations in 2026 and beyond.