6-Bromo-5-fluoropicolinic acid
- CAS No.1052714-46-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
6-Bromo-5-fluoropicolinic acid is a high-purity pharmaceutical intermediate used in the synthesis of mGluR5 antagonists. We offer competitive bulk pricing and reliable global supply.
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Product Overview
6-Bromo-5-fluoropicolinic acid represents a critical halogenated pyridine derivative utilized extensively in modern medicinal chemistry and pharmaceutical research. As a specialized building block, this compound features a unique substitution pattern that enables precise molecular modifications during complex organic synthesis. Our facility produces this intermediate under strict quality control standards to ensure consistency for downstream drug discovery programs.
The presence of both bromine and fluorine substituents on the picolinic acid scaffold provides chemists with versatile handles for cross-coupling reactions and nucleophilic substitutions. This chemical profile makes it an invaluable asset for developing novel therapeutic agents, particularly in the realm of neurological research where specific receptor modulation is required.
Technical Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 6-Bromo-5-fluoropicolinic acid |
| CAS Number | 1052714-46-1 |
| Molecular Formula | C6H3BrFNO2 |
| Molecular Weight | 219.996 g/mol |
| Purity | ≥99.0% |
| Density | 1.9±0.1 g/cm3 |
| Boiling Point | 331.3±42.0 °C at 760 mmHg |
| Flash Point | 154.2±27.9 °C |
Industrial Applications
This compound is primarily employed as a key intermediate in the synthesis of metabotropic glutamate receptor 5 (mGluR5) antagonists. These target molecules are investigated for their potential in treating neuropathic pain and other central nervous system disorders. The high purity level of our product ensures minimal side reactions during multi-step synthesis, thereby improving overall yield and reducing purification costs for our partners.
Beyond neurological therapeutics, fluorinated pyridine carboxylic acids are increasingly relevant in agrochemical development and material science. The robust carbon-fluorine bond enhances metabolic stability in biological systems, making this scaffold a preferred choice for lead optimization in drug discovery pipelines. Researchers rely on consistent quality to validate biological assays and scale up production efficiently.
Quality Assurance and Storage
We implement rigorous analytical testing protocols including HPLC, NMR, and Mass Spectrometry to verify the identity and purity of every batch. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) to guarantee compliance with specified parameters. Our commitment to industrial purity standards supports seamless integration into your manufacturing process.
- Packaged in 25 KGS drums for secure bulk transport.
- Stored in tightly closed containers to prevent moisture absorption.
- Kept in a cool, dry environment to maintain chemical stability.
- Global shipping capabilities with appropriate hazardous material handling.
Partner with us for reliable supply chain solutions tailored to the demanding requirements of the pharmaceutical industry. Our team is ready to assist with technical inquiries and custom synthesis requests to support your innovation goals.
