Industrial Purity 3-(Trifluoromethoxy)Bromobenzene COA Specs and Bulk Supply
- Guaranteed purity ≥99.0% with comprehensive COA documentation.
- Optimized manufacturing process minimizing dibrominated impurities.
- Global bulk supply capacity with customizable packaging options.
In the realm of advanced pharmaceutical synthesis and agrochemical development, the demand for high-quality fluorinated aromatics continues to rise. 3-(Trifluoromethoxy)bromobenzene, identified by CAS Number 2252-44-0, stands out as a critical precursor for constructing complex molecular architectures. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. specializes in delivering this compound with strict adherence to industrial purity standards, ensuring consistency for large-scale production runs.
This chemical substance serves as a versatile Fluorinated building block, enabling chemists to introduce both bromine and trifluoromethoxy functionalities into target molecules. The trifluoromethoxy group is particularly valued for its ability to enhance metabolic stability and lipophilicity in drug candidates. Consequently, securing a reliable supply chain with verified Certificate of Analysis (COA) data is paramount for procurement managers and process chemists alike.
Technical Specifications and Physical Properties
Quality control in fine chemical manufacturing relies heavily on precise physical constants. For 1-Bromo-3-(trifluoromethoxy)benzene, deviations in boiling point or density can indicate the presence of isomers or unreacted starting materials. Our production batches are rigorously tested to meet or exceed the following specifications:
| Property | Specification | Test Method |
|---|---|---|
| Chemical Name | 3-(Trifluoromethoxy)bromobenzene | GC-MS |
| CAS Number | 2252-44-0 | N/A |
| Purity (GC Area) | ≥ 99.0% | Gas Chromatography |
| Boiling Point | 156-158 °C | Distillation |
| Density | 1.62 g/mL at 25 °C | Pychnometer |
| Refractive Index | n20/D 1.462 | Refractometry |
| Appearance | Clear, Colorless to Almost Colorless Liquid | Visual |
| Water Content | ≤ 0.1% | Karl Fischer |
Maintaining the refractive index within the narrow range of 1.462 is a key indicator of structural integrity. Furthermore, the density value of 1.62 g/mL helps distinguish the product from potential chlorinated analogs or lower-density organic solvents that might remain after workup.
Optimized Synthesis Route and Impurity Profile
The manufacturing process for 3-Bromo-1-(trifluoromethoxy)benzene requires careful control to avoid over-bromination. Traditional methods involving bromine in acetic acid media often struggle with selectivity, leading to significant formation dibrominated derivatives. In comparative experiments, standard protocols have shown up to 41% dibrominated byproducts, which are difficult to separate via simple distillation due to close boiling points.
At NINGBO INNO PHARMCHEM CO.,LTD., we utilize an optimized catalytic system that enhances mono-selectivity. This approach significantly reduces the burden on downstream purification, resulting in higher overall yields and superior industrial purity. By minimizing side reactions, we ensure that the final Organic intermediate delivered to clients requires minimal additional processing before being used in subsequent coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig aminations.
When sourcing high-purity Organic intermediate materials, buyers should prioritize suppliers who provide detailed impurity profiles alongside their COA. Understanding the specific nature of residual starting materials, such as trifluoromethoxyaniline, is crucial for safety and reaction reproducibility.
COA Documentation and Compliance
Regulatory compliance in the pharmaceutical sector demands transparent documentation. Every shipment of CAS 2252-44-0 is accompanied by a comprehensive COA that details batch-specific analysis. This document includes data on heavy metals, residual solvents, and assay purity. For international clients, we also provide MSDS (Material Safety Data Sheets) and support third-party inspections such as SGS or BV before loading.
The safety profile of this compound classifies it as an irritant (GHS07). Proper handling procedures include the use of eyeshields, gloves, and appropriate respirator cartridges. Storage recommendations dictate that the material be kept sealed in a dry environment at room temperature to prevent hydrolysis or contamination. Our packaging typically consists of 25kg drums, though customization is available to suit specific logistic requirements.
Bulk Procurement and Market Availability
Market trends indicate a steady increase in demand for fluorinated intermediates driven by oncology and metabolic disease research. Supply chain stability is a common concern, with fluctuating bulk price structures observed across different regions. As an integrated producer, we maintain a robust supply ability, capable of fulfilling orders ranging from kilogram-scale samples to multi-ton annual contracts.
Our logistics network supports shipping by sea, air, or express courier for urgent sample requests. We understand that time-to-market is critical for our partners. Therefore, we streamline our order processing to ensure rapid dispatch while maintaining the highest quality standards. For regular customers, flexible payment terms and long-term supply agreements are available to mitigate market volatility.
Conclusion
Selecting the right supplier for 3-(Trifluoromethoxy)bromobenzene involves more than just comparing unit costs; it requires confidence in technical capability and quality assurance. With a commitment to optimized synthesis routes and rigorous testing protocols, NINGBO INNO PHARMCHEM CO.,LTD. ensures that every batch meets the exacting standards required for modern chemical synthesis. Contact our technical sales team today to request a sample or discuss your bulk procurement needs.