1-Bromo-3-(Trifluoromethoxy)Benzene Synthesis Route Manufacturing
Overcoming Selectivity Challenges in 1-Bromo-3-(trifluoromethoxy)benzene Production
Traditional direct bromination of trifluoromethoxybenzene often fails to achieve the required meta-substitution, leading to ortho and para byproducts that compromise yield. To address this, our optimized synthesis route utilizes a selective bromination of trifluoromethoxyaniline followed by deamination. This manufacturing process avoids polybrominated derivatives, ensuring high efficiency for this critical Organic intermediate. By controlling reaction conditions with weak acids and specific brominating agents, we eliminate the need for excessive deactivation steps, securing consistent output for R&D and production scales.
Formulation Compatibility and Drop-In Replacement Advantages
Engineered for seamless integration into complex chemical pathways, 3-(Trifluoromethoxy)bromobenzene offers superior stability and reactivity. Our material is designed to meet the rigorous demands of pharmaceutical and agrochemical synthesis.
- High Reactivity: Facilitates efficient cross-coupling and nucleophilic substitution reactions.
- Thermal Stability: Maintains integrity under standard processing temperatures up to 161.9°C.
- Solubility Profile: Compatible with common organic solvents such as methylene chloride and acetic acid.
- Consistent Quality: Batch-to-batch reproducibility ensures reliable downstream processing.
Technical Specifications and Analytical Methods
Quality control is paramount for maintaining industrial purity standards. The following table outlines the key physical and chemical properties verified during production.
| Parameter | Specification |
|---|---|
| CAS Number | 2252-44-0 |
| Chemical Name | 3-(Trifluoromethoxy)bromobenzene |
| Molecular Formula | C7H4BrF3O |
| Molecular Weight | 241.005 |
| Purity | 97% min (Distilled >99.5%) |
| Boiling Point | 161.9±35.0 °C at 760 mmHg |
| Appearance | Pale Yellow Liquid |
| Analysis Method | GC-MS, HPLC |
Strict Quality Assurance (QA) Workflow and COA Verification
At NINGBO INNO PHARMCHEM CO.,LTD., every batch undergoes rigorous testing to validate composition and safety. Our QA workflow includes raw material inspection, in-process control during bromination and deamination, and final distillation verification. Customers can access detailed documentation, including Industrial Purity 3-(Trifluoromethoxy)Bromobenzene Coa Specs, to ensure compliance with internal standards. This transparency supports procurement teams in verifying material suitability before scale-up.
Secure your supply chain with reliable sourcing and competitive market analysis, such as our report on 3-(Trifluoromethoxy)Bromobenzene Bulk Price 2026. To request a batch-specific COA, SDS, or secure a bulk pricing quote, please contact our technical sales team.