6-Fluoro-2-Methyl-3-Nitropyridine Bulk Price Quotes 2026
- Market Dynamics: Gram-scale listings often exceed $100, while kilogram bulk orders significantly reduce unit costs.
- Technical Specs: Typical industrial purity reaches 97%-98% with strict control over halogenated byproducts.
- Procurement: Reliable supply chains require verified COA documentation and optimized logistics for hazardous intermediates.
The procurement of specialized heterocyclic intermediates is a critical step in the development of novel pharmaceutical agents and agrochemicals. Among these, 6-Fluoro-2-Methyl-3-Nitropyridine stands out as a versatile fluorinated pyridine derivative used extensively in nucleophilic aromatic substitution reactions. For process chemists and procurement managers looking toward 2026, understanding the correlation between synthesis complexity, purity grades, and bulk price structures is essential for budget forecasting and supply chain stability.
As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. recognizes that accurate costing models depend on more than just spot prices. They require an analysis of the manufacturing process, yield optimization, and the scalability of production routes. This article provides a technical breakdown of market pricing trends, quality specifications, and strategic sourcing advice for this high-value heterocyclic building block.
Global Market Pricing Trends for Kilogram vs Gram Quantities
Market data indicates a steep volatility in pricing depending on the order volume. Small-scale research quantities, typically ranging from 100mg to 25g, often carry a premium due to packaging, handling, and inventory overhead. Historical listings for similar nitro pyridine compounds show gram-scale prices fluctuating between $20 and $100 per gram. However, this model does not reflect commercial manufacturing realities.
When transitioning to pilot plant or commercial scales, the cost per kilogram drops precipitously. Bulk procurement eliminates the marginal costs associated with retail packaging and allows for optimized batch production. For 2026, buyers should anticipate that kilogram-level quotes will offer substantial savings compared to aggregated gram purchases. The price disparity highlights the importance of securing a direct manufacturing partner rather than relying on chemical distributors who aggregate small lots.
Key factors influencing the 2026 price landscape include:
- Raw Material Costs: Fluctuations in the price of fluorinating agents and nitro precursors.
- Energy Consumption: The energy-intensive nature of nitration and halogenation steps.
- Regulatory Compliance: Costs associated with environmental safety and waste disposal in synthesis facilities.
Technical Specifications and Industrial Purity Standards
Quality consistency is paramount when integrating this intermediate into multi-step synthesis routes. The physical and chemical properties of the compound dictate its handling and storage requirements. Standard industrial purity for this material typically targets 97% to 98%, with specific limits on isomeric impurities and residual solvents.
Below is a summary of typical technical specifications expected from a high-quality supplier:
| Property | Specification |
|---|---|
| CAS Number | 18605-16-8 |
| Molecular Formula | C6H5FN2O2 |
| Molecular Weight | 156.11 g/mol |
| Purity (HPLC) | > 97.0% |
| Melting Point | Approx. 30°C |
| Boiling Point | 266.2±35.0 °C (Predicted) |
| Density | 1.357±0.06 g/cm³ |
| Storage Conditions | 2-8°C under inert gas (Nitrogen/Argon) |
Maintaining these specifications requires rigorous quality control. A comprehensive COA (Certificate of Analysis) should accompany every batch, detailing impurity profiles and confirming the absence of hazardous byproducts. When sourcing high-purity 6-Fluoro-2-Methyl-3-Nitropyridine, buyers should verify that the supplier utilizes advanced chromatographic methods to ensure batch-to-batch consistency. This level of documentation is critical for regulatory filings and process validation.
Synthesis Route and Yield Optimization
The synthesis route for this nitro pyridine compound generally involves the selective nitration of a fluorinated methylpyridine precursor. Controlling the regioselectivity is the primary challenge, as improper conditions can lead to unwanted isomers such as 2-Fluoro-6-methyl-5-nitropyridine or other positional variants. High-yield processes minimize these byproducts, directly impacting the final bulk price by reducing waste and purification costs.
Optimized manufacturing processes focus on:
- Temperature Control: Precise management during nitration to prevent over-oxidation.
- Catalyst Selection: Using specific acid systems to direct substitution to the 3-position.
- Purification: Efficient crystallization or distillation to achieve the required 98% assay.
Requesting Custom Volume Discounts and Logistics Quotes
For organizations planning large-scale production, engaging directly with the manufacturer is the most effective strategy to secure favorable terms. NINGBO INNO PHARMCHEM CO.,LTD. offers tailored solutions for clients requiring metric ton quantities, ensuring that logistics and packaging align with safety regulations for hazardous materials.
When requesting a quote for 2026 delivery, procurement teams should provide the following details to ensure accuracy:
- Target Volume: Estimated annual consumption in kilograms or tons.
- Purity Requirements: Specific thresholds for water content and isomeric impurities.
- Packaging Preferences: Drum sizes or bulk container specifications.
- Destination: Shipping location to calculate freight and insurance costs.
Strategic sourcing also involves evaluating the supplier's capacity for technical support. A reliable partner will assist with troubleshooting synthesis issues and provide stability data for long-term storage. By prioritizing manufacturers with proven track records in fluorinated chemistry, buyers can mitigate supply chain risks and secure competitive pricing for the coming fiscal year.
In conclusion, while spot prices for small quantities remain high, the bulk market for 6-Fluoro-2-Methyl-3-Nitropyridine offers significant cost efficiencies for committed partners. Focus on industrial purity, verified synthesis routes, and direct manufacturer relationships to optimize your procurement strategy for 2026.