6-Methyl-5-Nitropyridin-2-Ol Industrial Purity Coa Specs
- Critical Specifications: Melting point ranges between 233°C to 236°C indicate high crystalline integrity.
- Purity Standards: Industrial grade requires >98% assay with strict limits on regioisomeric impurities.
- Supply Chain: Reliable bulk procurement depends on verified manufacturing process documentation.
In the landscape of heterocyclic organic synthesis, few intermediates offer the versatility required for complex pharmaceutical and agrochemical scaffolding quite like nitro-functionalized pyridines. Specifically, 6-Methyl-5-nitropyridin-2-ol serves as a critical building block for nucleophilic substitution reactions and reduction pathways leading to aminopyridines. For process chemists and procurement managers, understanding the nuanced differences between research-grade samples and true industrial purity is paramount for scaling production without compromising yield or safety.
As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. emphasizes the importance of rigorous quality control in the production of high-value intermediates. This article details the technical specifications, synthesis considerations, and certificate of analysis (COA) parameters essential for bulk buyers evaluating this chemical entity.
Chemical Identity and Physical Properties
Accurate identification is the first step in quality assurance. This compound exists in tautomeric equilibrium, often referred to interchangeably in literature as the pyridinone or the pyridinol form. Common synonyms include 6-Hydroxy-3-nitro-2-picoline and 2-Hydroxy-5-nitro-6-methylpyridine. Regardless of nomenclature, the physical constants remain consistent across high-quality batches. Procurement teams must verify these constants against incoming shipments to ensure material suitability.
The following table outlines the standard technical specifications expected for commercial-grade material suitable for multi-kilogram synthesis:
| Parameter | Specification | Test Method |
|---|---|---|
| Chemical Name | 6-Methyl-5-nitro-1H-pyridin-2-one | NMR / MS |
| CAS Number | 28489-45-4 | Registry Search |
| Molecular Formula | C6H6N2O3 | Calculation |
| Molecular Weight | 154.13 g/mol | Calculation |
| Appearance | Yellow to Orange Crystalline Powder | Visual |
| Melting Point | 233°C to 236°C | DSC / Capillary |
| Assay (Purity) | > 98.0% | HPLC |
| Loss on Drying | < 0.5% | Karl Fischer / LOD |
Optimizing the Synthesis Route for Scale
The commercial viability of this intermediate hinges on a robust synthesis route. Typically, the manufacturing process involves the nitration of 2-hydroxy-6-methylpyridine. However, regioselectivity is a significant challenge. Uncontrolled nitration can lead to the formation of unwanted isomers, such as the 3-nitro or 4-nitro variants, which are difficult to separate due to similar physical properties.
Advanced manufacturing protocols utilize controlled temperature profiles and specific nitrating agents to maximize the yield of the 5-nitro isomer. For buyers, understanding the manufacturing process behind the material is crucial. A supplier capable of maintaining low isomeric impurity profiles demonstrates superior process control. This directly impacts downstream processing, where impurities can poison catalysts during subsequent hydrogenation steps or complicate purification during final API crystallization.
When sourcing high-purity 6-Methyl-5-nitro-1H-pyridin-2-one, buyers should request detailed impurity profiles alongside the standard COA. This ensures that the material aligns with the specific tolerances of your reaction pathway.
Interpreting the Certificate of Analysis (COA)
A Certificate of Analysis is more than a compliance document; it is a fingerprint of the batch quality. For 6-Methyl-5-nitropyridin-2-ol, the COA must provide transparency on several critical fronts beyond simple assay percentage. Heavy metal content, residual solvents, and specific organic impurities must be quantified.
Key data points to scrutinize on a COA include:
- Chromatographic Purity: HPLC traces should show a single dominant peak with no significant shoulders indicating isomeric contamination.
- Residual Solvents: Compliance with ICH Q3C guidelines is mandatory for pharmaceutical intermediates.
- Particle Size Distribution: For solid-state processing, consistent particle size ensures uniform dissolution and reaction kinetics.
Discrepancies in melting point, such as a range wider than 3°C or a depression below 230°C, often indicate significant contamination. Reliable suppliers provide batch-specific data rather than generic specification sheets.
Commercial Considerations and Bulk Procurement
Transitioning from gram-scale research to tonnage production requires a partner capable of consistent supply. Market fluctuations can affect bulk price stability, often driven by raw material availability for the pyridine precursors. Establishing a long-term contract with a manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. mitigates these risks by securing allocation and price stability.
Furthermore, logistics play a vital role. This compound is classified under specific hazard categories due to its nitro functionality. Proper packaging and hazardous material handling declarations are essential for international shipping. Buyers should verify that the supplier has experience exporting chemical intermediates to their specific region to avoid customs delays.
Conclusion
Securing a reliable supply of 6-hydroxy-2-methyl-3-nitropyridine derivatives requires a deep understanding of technical specifications and manufacturing capabilities. By prioritizing vendors who offer transparent COAs, robust synthesis routes, and proven industrial purity, procurement teams can ensure seamless scale-up. For projects demanding the highest standards of quality and consistency, partnering with an established entity ensures that your supply chain remains resilient and compliant.