Intermediates

6-Methyl-5-nitro-1H-pyridin-2-one

  • CAS No.28489-45-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 6-Methyl-5-nitro-1H-pyridin-2-one (CAS 28489-45-4), a versatile pyridine-based intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.

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Product Technical Details

Product Overview

6-Methyl-5-nitro-1H-pyridin-2-one is a high-value heterocyclic compound belonging to the substituted pyridinone family. With its distinct nitro and hydroxyl functional groups positioned on a methylated pyridine ring, this molecule serves as a critical building block in multi-step organic syntheses. It is widely employed in the development of complex pharmaceutical active ingredients and specialty agrochemicals due to its reactivity and structural versatility.

Specifications

Molecular FormulaC6H6N2O3
Molecular Weight154.12 g/mol
CAS Number28489-45-4
AppearanceLight brown to brown crystalline powder
Assay≥98.0%
Moisture≤0.5%
Melting Point230–232°C
Density1.36 g/cm³
Boiling Point326.4°C
Flash Point151.2°C

Industrial Applications

This compound is primarily utilized as an intermediate in fine chemical manufacturing. Its applications include:

  • Serving as a key precursor in the synthesis of bioactive molecules targeting neurological and metabolic pathways.
  • Functioning as a scaffold in medicinal chemistry for constructing novel kinase inhibitors and antimicrobial agents.
  • Acting as a functionalized core in the development of crop protection agents with enhanced selectivity.

Due to its electron-deficient aromatic system, it readily participates in nucleophilic substitution, reduction, and cross-coupling reactions, making it indispensable in modern synthetic routes.

Handling and Storage

Store in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Keep container tightly closed when not in use. Standard industrial hygiene practices should be followed during handling. Packaging is typically provided in 25 kg drums, with custom options available upon request.