1-Bromomethyl-2-Trifluoromethylbenzene Bulk Price Global Manufacturer
- Direct access to tiered pricing structures for kilogram to metric ton-scale procurement.
- Verified industrial purity standards exceeding 98.5% via GC and HPLC analysis.
- Streamlined logistics for hazardous aromatic halides with full regulatory compliance.
In the realm of advanced organic synthesis, 1-Bromomethyl-2-Trifluoromethylbenzene (CAS: 395-44-8) serves as a critical electrophilic building block for pharmaceuticals and agrochemicals. As a specialized fluorinated building block, this compound enables the introduction of the trifluoromethyl group, which significantly enhances metabolic stability and lipophilicity in final drug candidates. Sourcing this material requires a partner capable of maintaining strict quality control over the bromination process to minimize dibrominated impurities and unreacted starting materials.
Procurement teams evaluating the bulk price of this intermediate must look beyond unit cost to consider total value, including consistency of supply, technical support, and regulatory documentation. As a premier global manufacturer, understanding the synthesis capabilities and quality assurance protocols is essential for securing long-term supply chains. This article details the commercial and technical considerations for acquiring high-grade 2-(Trifluoromethyl)benzylbromide for industrial applications.
Technical Specifications and Synthesis Route
The production of high-quality 2-Trifluoromethylbenzyl bromide typically involves the free-radical bromination of 2-(trifluoromethyl)toluene. Controlling the reaction temperature and the stoichiometric ratio of the brominating agent is vital to achieving high industrial purity. Side reactions, such as ring bromination or over-bromination to the dibromide, must be suppressed through precise catalytic initiation and process monitoring.
Quality control laboratories utilize Gas Chromatography (GC) and High-Performance Liquid Chromatography (HPLC) to verify assay levels. A robust synthesis route ensures that residual solvents and heavy metals remain within ICH Q3 guidelines. Below is a standard specification table for the industrial grade material:
| Parameter | Specification | Test Method |
|---|---|---|
| Chemical Name | 1-(Bromomethyl)-2-(trifluoromethyl)benzene | - |
| CAS Number | 395-44-8 | - |
| Molecular Formula | C8H6BrF3 | - |
| Molecular Weight | 239.03 g/mol | - |
| Purity (GC Area %) | ≥ 98.5% | GC-MS |
| Water Content | ≤ 0.1% | Karl Fischer |
| Appearance | Colorless to Pale Yellow Liquid | Visual |
When sourcing high-purity 1-(Bromomethyl)-2-(Trifluoromethyl)Benzene, buyers should request a Certificate of Analysis (COA) that details specific impurity profiles, particularly focusing on isomeric bromides and free bromine content. This level of transparency is crucial for downstream process validation.
Volume-Based Discount Structures
Pricing for aromatic halides is heavily dependent on order volume and contract duration. Spot purchases for laboratory-scale quantities naturally carry a higher unit cost due to packaging and handling overheads. However, industrial consumers benefit from significant economies of scale. Manufacturers typically offer tiered pricing structures that reduce the cost per kilogram as volumes increase from drums to isotanks.
Long-term supply agreements often lock in raw material costs, protecting buyers from volatility in bromine and fluorinated precursor markets. For clients requiring custom synthesis or specific packaging configurations, such as nitrogen-blanked drums to prevent hydrolysis, negotiated rates are available. It is advisable to discuss annual consumption forecasts early in the negotiation process to secure the most favorable bulk price terms.
Direct Manufacturer Sourcing Benefits
Engaging directly with a production facility eliminates intermediary markups and reduces communication latency regarding technical queries. NINGBO INNO PHARMCHEM CO.,LTD. operates as a top-tier manufacturer, providing direct access to process chemists who can troubleshoot application-specific issues. This direct line of communication ensures that any deviations in quality are addressed immediately at the source.
Furthermore, direct sourcing guarantees the authenticity of the material. In the global chemical market, repackaged goods can sometimes introduce contamination risks. By procuring directly from NINGBO INNO PHARMCHEM CO.,LTD., clients receive material produced under consistent Good Manufacturing Practices (GMP) or ISO-certified quality systems. This reliability is particularly important for benzyl bromide derivative intermediates used in regulated industries where supply chain traceability is mandatory.
Procurement Lead Times and Logistics
Logistics for fluorinated intermediates require careful handling due to their classification as hazardous materials. 2-(Bromomethyl)benzotrifluoride is typically classified under hazardous goods regulations for sea and air freight. Lead times are influenced by production scheduling, customs clearance, and transportation mode.
Standard lead times for stock items range from 1 to 2 weeks, while campaign production for large volumes may require 4 to 6 weeks. Packaging options usually include 25kg or 200kg drums, often lined with suitable materials to prevent corrosion. For international shipments, full documentation including Safety Data Sheets (SDS), transportation classification, and certificates of origin are provided to ensure smooth customs clearance. Efficient logistics management ensures that this critical alpha-bromo-2-trifluoromethyltoluene derivative arrives on schedule, preventing downstream production delays.
In conclusion, securing a reliable supply of this key intermediate involves balancing technical specifications with commercial terms. By prioritizing industrial purity, verified synthesis routes, and direct manufacturer relationships, procurement managers can optimize both cost and quality for their synthetic workflows.