Bulk Price 2-Bromo-N-Methyl-N-(4-Nitrophenyl)Acetamide Global Manufacturer
- High-Yield Synthesis: Optimized bromination routes ensure consistent >98% assay purity for downstream API production.
- Cost-Efficient Scaling: Tiered bulk price structures available for kilogram to multi-ton procurement cycles.
- Strict Cold Chain: Mandatory -20°C storage and shipping protocols maintain chemical stability during global transit.
In the competitive landscape of kinase inhibitor production, securing a reliable supply chain for critical building blocks is paramount. 2-Bromo-N-methyl-N-(4-nitrophenyl)acetamide (CAS: 23543-31-9) serves as a vital pharmaceutical intermediate in the synthesis of Nintedanib, a approved therapy for idiopathic pulmonary fibrosis and non-small cell lung cancer. Procurement teams must evaluate suppliers not only on cost but on technical capability, impurity profiles, and logistical reliability. This analysis details the commercial and technical considerations for sourcing this specialized bromoacetamide derivative at an industrial scale.
Wholesale Pricing Tiers and Volume Discounts
The bulk price of 2-Bromo-N-methyl-N-(4-nitrophenyl)acetamide is influenced by several volatility factors in the fine chemicals market. Primary cost drivers include the availability of brominating agents and the precursor N-methyl-4-nitroaniline. Fluctuations in elemental bromine pricing can impact lead times and final quotes. However, established manufacturers mitigate these risks through forward contracting of raw materials.
For B2B purchasers, pricing is typically structured into volume tiers. Laboratory-scale quantities (grams to low kilograms) command a premium due to packaging and quality control overheads. In contrast, industrial drums (25kg) and bulk tote shipments offer significant unit cost reductions. When negotiating contracts, buyers should request transparency on the cost breakdown regarding purification steps. Achieving industrial purity often requires recrystallization or column chromatography, which adds to the operational expense but is necessary to meet downstream API specifications.
Additionally, Incoterms play a crucial role in the landed cost. Given the thermal sensitivity of this compound, shipping terms must account for temperature-controlled logistics. Suppliers offering FOB (Free on Board) pricing may appear cheaper initially, but the cost of maintaining the cold chain during ocean freight must be factored into the total budget. A comprehensive quote should include validation of the packaging integrity to prevent hydrolysis of the bromoacetyl group during transit.
Verified Global Manufacturer Capabilities
Technical due diligence is essential when selecting a global manufacturer for sensitive intermediates. The molecular formula C9H9BrN2O3 and molecular weight of 273.08 g/mol indicate a structure susceptible to nucleophilic attack if moisture is present. Therefore, manufacturing facilities must operate under strict humidity controls. Leading producers utilize closed-system reactors for the acylation step to minimize exposure to atmospheric moisture, thereby reducing the formation of hydrolytic impurities.
Quality assurance protocols should align with international standards. Buyers should request a Certificate of Analysis (COA) that details not only the main assay but also specific impurity levels, such as residual solvents and heavy metals. The synthesis route typically involves the reaction of N-methyl-4-nitroaniline with bromoacetyl bromide in a suitable solvent like dichloromethane or toluene, followed by a neutralization step. Controlling the reaction temperature is critical to prevent dibromination or over-acylation side reactions.
When sourcing high-purity 2-Bromo-N-methyl-N-(4-nitrophenyl)acetamide, buyers should verify that the supplier employs HPLC and NMR spectroscopy for batch release testing. NINGBO INNO PHARMCHEM CO.,LTD. maintains rigorous quality control benchmarks to ensure each batch meets the stringent requirements for use as a Nintedanib intermediate. This level of oversight minimizes the risk of production delays in the final API synthesis, where impurity carryover can be costly to remove.
Storage specifications are non-negotiable for this compound. Technical data sheets indicate a storage temperature of -18°C to -20°C. A capable manufacturer will have dedicated cold storage warehouses and the ability to ship via refrigerated containers. Failure to maintain this temperature profile can lead to decomposition, rendering the material unsuitable for GMP manufacturing environments.
Technical Specification Overview
| Parameter | Specification |
|---|---|
| Product Name | 2-Bromo-N-methyl-N-(4-nitrophenyl)acetamide |
| CAS Number | 23543-31-9 |
| Molecular Formula | C9H9BrN2O3 |
| Molecular Weight | 273.08 g/mol |
| Purity (HPLC) | ≥ 98.0% (Industrial Grade) |
| Storage Condition | -20°C (Freezer) |
| Appearance | Off-white to Pale Yellow Solid |
Alternative nomenclature such as N-bromoacetyl-N-methyl-4-nitro-aniline may appear in legacy documentation or specific regional regulatory filings. It is important for procurement officers to recognize these synonyms to ensure accurate customs classification and safety data sheet (SDS) alignment. Consistency in naming conventions across the supply chain prevents logistical errors during import/export clearance.
Requesting Custom Bulk Quotes for 2026
Planning for future production cycles requires accurate forecasting of raw material availability. As demand for antifibrotic agents continues to grow, securing long-term supply agreements for key intermediates is a strategic advantage. Buyers should initiate discussions with suppliers early to lock in capacity for the 2026 fiscal year. Custom bulk quotes should specify the required packaging format, whether it be fiber drums with polyethylene liners or specialized containers for hazardous materials.
When submitting a request for quotation (RFQ), include detailed requirements regarding documentation. Beyond the standard COA, many API manufacturers require validation packages that include method validation reports and stability data. NINGBO INNO PHARMCHEM CO.,LTD. supports these requests with comprehensive technical dossiers to facilitate regulatory submissions. Transparency in the synthesis route declaration is also often required to assess potential genotoxic impurity risks.
Lead times vary based on current inventory levels and production scheduling. While stock items may ship within days, made-to-order batches typically require 4 to 6 weeks for synthesis, purification, and quality testing. For large-scale tonnage orders, a phased delivery schedule may be negotiated to align with the buyer's production campaigns, reducing inventory holding costs. By partnering with a technically proficient manufacturer, pharmaceutical companies can ensure a steady flow of high-quality intermediates, safeguarding their own production timelines and market supply.