4-Bromo-3-Formylphenoxy Benzonitrile Bulk Price Factory Direct
- High Purity Standards: Manufactured with industrial purity exceeding 99.0% HPLC area normalization.
- Cost Efficiency: Factory direct pricing models available for metric ton-scale procurement.
- Global Logistics: Secure packaging in 25kg drums with comprehensive COA documentation.
In the competitive landscape of pharmaceutical synthesis, securing a reliable supply chain for key building blocks is paramount. 4-(4-Bromo-3-formylphenoxy)benzonitrile, identified by CAS Registry Number 906673-54-9, serves as a critical Pharmaceutical intermediate in the production of advanced therapeutic agents. Specifically, this compound is widely recognized as a Crisaborole Intermediate, utilized in the manufacturing of non-steroidal phosphodiesterase-4 (PDE4) inhibitors. For procurement managers and process chemists, understanding the technical specifications and commercial dynamics of this molecule is essential for maintaining production schedules and cost margins.
As a global manufacturer committed to quality, NINGBO INNO PHARMCHEM CO.,LTD. provides comprehensive data on the synthesis and supply of this specialized nitrile derivative. The following analysis details the manufacturing process, quality control parameters, and bulk pricing structures available for industrial buyers.
Technical Specifications and Synthesis Route
The molecular formula for this compound is C14H8BrNO2, with a molecular weight of 302.12 g/mol. The structural integrity of the molecule relies on the precise positioning of the bromo and formyl groups on the phenoxy ring relative to the benzonitrile moiety. Achieving high industrial purity requires a controlled manufacturing process that minimizes regioisomers and unreacted starting materials.
The typical synthesis route involves a nucleophilic aromatic substitution reaction. A phenolate derivative reacts with a halogenated benzonitrile under basic conditions. Process optimization focuses on solvent selection and temperature control to maximize yield while suppressing side reactions such as hydrolysis of the nitrile group. Strict quality control protocols are implemented at every stage, ensuring that the final product meets the rigorous demands of downstream API synthesis.
When sourcing high-purity 4-(4-Bromo-3-formylphenoxy)benzonitrile, buyers should verify the Certificate of Analysis (COA) for specific impurity profiles. Key parameters include residual solvents, heavy metals, and related substances. NINGBO INNO PHARMCHEM CO.,LTD. ensures that every batch is accompanied by a detailed COA, providing transparency on chromatographic purity and physical properties.
Quality Control Parameters
To guarantee consistency across batches, the following technical specifications are maintained:
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | Off-white to Light Yellow Powder | Visual |
| Purity (HPLC) | ≥ 99.0% | Area Normalization |
| Loss on Drying | ≤ 0.5% | Karl Fischer / LOD |
| Residual Solvents | Compliant with ICH Q3C | GC HeadSpace |
| Heavy Metals | ≤ 10 ppm | ICP-MS |
Wholesale Pricing Tiers for Bulk Orders
Pricing for fine chemicals is heavily dependent on order volume and contract duration. For 4-Bromo-3-formylphenoxy benzonitrile, the bulk price decreases significantly as procurement scales from laboratory quantities to industrial metric tons. Buyers should anticipate tiered pricing structures that reflect the efficiencies of large-scale production runs.
Factory direct engagement eliminates intermediary markups, allowing for more competitive rates. Typically, pricing tiers are structured around kilogram, multi-kilogram, and tonnage brackets. Long-term supply agreements often lock in rates, protecting buyers from market volatility associated with raw material fluctuations, such as changes in the cost of brominated precursors or energy inputs required for the reaction.
Cost Drivers in Manufacturing
Several factors influence the final cost per kilogram for this intermediate:
- Raw Material Availability: Fluctuations in the cost of 4-hydroxybenzonitrile and brominated aldehydes.
- Process Yield: Higher yields reduce waste disposal costs and raw material consumption per unit of output.
- Purification Requirements: Achieving >99.5% purity may require additional recrystallization steps, impacting labor and solvent costs.
- Regulatory Compliance: Adherence to environmental and safety standards adds to operational overhead but ensures supply continuity.
Factory Direct Supply Chain Benefits
Procuring directly from a manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. offers distinct advantages over trading companies. The primary benefit is traceability. In a factory direct model, the buyer has direct access to the production team, allowing for custom adjustments to specifications if required by the downstream synthesis. This level of collaboration is crucial when scaling from pilot plant to commercial production.
Furthermore, direct manufacturing ensures better inventory management. Production schedules can be aligned with the buyer’s consumption rates, reducing the need for excessive safety stock. This Just-In-Time (JIT) capability is vital for maintaining cash flow and minimizing warehouse storage costs for hazardous materials.
Global Shipping and 25kg Drum Packaging
Logistics play a critical role in the total landed cost of chemical intermediates. Standard packaging for 4-(4-Bromo-3-formylphenoxy)benzonitrile typically involves 25kg fiber drums with inner polyethylene liners. This packaging format ensures protection against moisture and contamination during transit. For larger volumes, bulk bags or customized container loading plans can be arranged to optimize shipping space.
Global shipping capabilities ensure that products reach manufacturing sites in Europe, North America, and Asia efficiently. Documentation support includes Safety Data Sheets (SDS), Certificates of Analysis, and customs declaration codes to facilitate smooth clearance. Reliable logistics partners are employed to handle hazardous material classifications where applicable, ensuring compliance with international transport regulations.
Conclusion
Securing a stable supply of high-quality intermediates is fundamental to pharmaceutical manufacturing success. By prioritizing industrial purity, transparent pricing, and robust logistics, buyers can mitigate supply chain risks. NINGBO INNO PHARMCHEM CO.,LTD. stands ready to support global partners with consistent quality and competitive factory direct solutions for this essential building block.