4-Bromo-1,2-Dichlorobenzene Bulk Price Industrial Purity Specs
- Technical Specifications: Typical assay ≥98.0% with strict control on isomeric impurities.
- Physical Properties: Melting point 22°C to 25°C; Boiling point 140°C to 142°C at 30 mmHg.
- Procurement: Volume-based pricing available for 25 kg drums and bulk IBC shipments.
In the landscape of fine chemical intermediates, 4-Bromo-1,2-dichlorobenzene (CAS: 18282-59-2) stands as a critical building block for pharmaceutical and agrochemical synthesis. Procuring this halogenated aromatic compound requires a deep understanding of technical specifications, isomeric purity, and volume-based pricing structures. For process chemists and procurement managers, securing a reliable supply chain is paramount to maintaining reaction yields and downstream product quality. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. provides comprehensive data to facilitate informed bulk purchasing decisions.
Technical Specifications and Physical Properties
Understanding the physicochemical profile of 1,2-dichloro-4-bromobenzene is essential for process design, particularly regarding distillation parameters and storage conditions. Industrial-grade material typically adheres to strict purity thresholds to minimize side reactions during nucleophilic substitutions or metal-catalyzed couplings. The following table outlines the standard specifications expected for high-quality bulk supply:
| Parameter | Specification |
|---|---|
| Chemical Name | 4-Bromo-1,2-dichlorobenzene |
| CAS Number | 18282-59-2 |
| Molecular Formula | C6H3BrCl2 |
| Molecular Weight | 225.91 g/mol |
| Assay (Purity) | ≥98.0% (GC Area) |
| Melting Point | 22°C to 25°C |
| Boiling Point | 140°C to 142°C (at 30 mmHg) |
| Density | 1.781 g/cm³ |
| Appearance | Colorless to light yellow liquid |
Maintaining the boiling point within the 140°C to 142°C range at reduced pressure is critical during vacuum distillation processes. Deviations often indicate the presence of higher boiling residues or lower boiling solvents, which can compromise the industrial purity required for sensitive catalytic cycles.
Synthesis Route and Isomeric Control
The synthesis route for this compound typically involves the bromination of 1,2-dichlorobenzene or chlorination of bromobenzene derivatives under controlled conditions. The primary challenge in manufacturing lies in managing regioselectivity to prevent the formation of structural isomers. Common impurities include 1-Bromo-3,4-dichlorobenzene and 2-Bromo-1,4-dichlorobenzene. While these isomers share similar molecular weights, their reactivity profiles differ significantly in cross-coupling reactions.
Advanced fractional distillation and crystallization techniques are employed to suppress 3,4-Dichloro-1-bromobenzene content to below 1.0%. For manufacturers producing active pharmaceutical ingredients (APIs), the presence of these isomers can lead to difficult-to-remove impurities in the final drug substance. Therefore, requesting a detailed Certificate of Analysis (COA) that specifies isomeric distribution is a standard best practice when evaluating suppliers.
Volume-Based Pricing Tiers for 25 kg Drums
The bulk price of halogenated intermediates is heavily influenced by order volume, packaging type, and logistical requirements. Small-scale laboratory purchases often incur significant premiums due to packaging and handling costs. In contrast, industrial procurement focuses on optimized logistics, such as 25 kg drums or bulk isotanks.
Pricing structures generally follow three tiers:
- Laboratory Scale (1-5 kg): Highest cost per unit, suitable for R&D and method development.
- Pilot Scale (25-100 kg): Moderate pricing, typically shipped in steel drums with nitrogen headspace.
- Commercial Scale (500 kg+): Most competitive rates, reflecting optimized manufacturing process efficiency and bulk freight consolidation.
When sourcing high-purity 4-Bromo-1,2-dichlorobenzene, buyers should negotiate based on annual consumption forecasts to secure favorable terms. Long-term contracts often lock in pricing against raw material volatility, particularly for bromine and chlorine feedstocks.
Impact of Assay ≥98.0% on Cost
The difference between 98% and 99% assay purity can have a nonlinear impact on cost. Achieving ≥99.0% purity often requires additional distillation passes or recrystallization steps, which reduce overall yield and increase energy consumption. For many industrial applications, an assay of ≥98.0% is sufficient, provided that specific impurities like 3,4-dichlorophenyl bromide are controlled.
Process chemists should evaluate whether the cost premium for higher purity translates to tangible benefits in their specific reaction workflow. In some cases, the extra cost does not improve the final yield but merely shifts the impurity burden to downstream purification stages. NINGBO INNO PHARMCHEM CO.,LTD. works closely with clients to define the optimal purity specification that balances cost efficiency with reaction performance.
Requesting Quotes from Global Manufacturers
Effective procurement extends beyond unit price. It involves verifying the supplier's capacity to maintain consistent quality over time. When requesting quotes, buyers should specify the following:
- Target Purity: Define acceptable limits for water content and isomeric impurities.
- Packaging Requirements: Confirm compatibility with existing storage facilities (e.g., drum type, labeling).
- Lead Time: Ensure the manufacturer can meet production schedules without delay.
- Regulatory Compliance: Verify adherence to safety standards such as REACH or TSCA where applicable.
Reliable supply chains are built on transparency. Manufacturers should provide batch-specific COAs and retain samples for traceability. By focusing on technical alignment and commercial flexibility, procurement teams can secure a stable supply of this vital intermediate.
Conclusion
Securing a reliable source of 4-Bromo-1,2-dichlorobenzene requires a partnership with a manufacturer who understands both the chemical nuances and the commercial realities of bulk supply. With strict control over isomeric impurities and flexible volume tiers, NINGBO INNO PHARMCHEM CO.,LTD. ensures that your production lines remain efficient and cost-effective. For detailed specifications and customized quotes, contact our technical sales team to discuss your specific requirements.