4-Bromo-1,2-dichlorobenzene
- CAS No.18282-59-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Bromo-1,2-dichlorobenzene (CAS 18282-59-2), a versatile halogenated aromatic intermediate for pharmaceutical and agrochemical synthesis.
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Product Overview
4-Bromo-1,2-dichlorobenzene (CAS 18282-59-2) is a highly valuable halogenated aromatic compound widely employed as a key building block in the synthesis of complex organic molecules. With its unique substitution pattern—featuring bromine and two adjacent chlorine atoms on the benzene ring—it offers excellent regioselectivity for cross-coupling reactions such as Suzuki, Stille, and Ullmann-type transformations. This makes it an indispensable intermediate in the development of active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.
Specifications
| Molecular Formula | C6H3BrCl2 |
|---|---|
| Molecular Weight | 225.90 g/mol |
| Appearance | Colorless to pale yellow liquid or solid |
| Assay | ≥98.0% |
| Water Content | ≤0.50% |
| Melting Point | 24–25 °C (lit.) |
| Boiling Point | 237.0 ± 0.0 °C at 760 mmHg |
| Density | 1.7 ± 0.1 g/cm³ |
| LogP | 3.94 |
| Water Solubility | Insoluble |
Industrial Applications
As a multifunctional aryl halide, 4-Bromo-1,2-dichlorobenzene serves primarily as a synthetic intermediate in the pharmaceutical and agrochemical industries. Its bromine atom is more reactive than the chlorine substituents under palladium-catalyzed conditions, enabling selective functionalization while preserving the dichloro motif for subsequent modifications. Common applications include:
- Synthesis of heterocyclic scaffolds for drug discovery programs
- Preparation of advanced intermediates for antifungal and anti-inflammatory agents
- Building block in the manufacture of high-performance polymers and liquid crystals
- Use in research laboratories for method development in C–H activation and halogen exchange chemistry
Stored in a cool, dry, and well-ventilated area with the container tightly sealed, this compound maintains stability under recommended conditions. Standard packaging is 25 kg per drum, with custom options available to meet specific industrial requirements.
