Bulk Price 4-Chloro-2-(Trifluoroacetyl)Aniline Hcl Manufacturer Analysis
- Technical Specification: CAS 173676-59-0, Molecular Formula C8H5ClF3NO.HCl, critical for Efavirenz API synthesis.
- Procurement Focus: Industrial purity standards exceed 98.5% with customizable packaging for bulk orders.
- Supply Chain: Reliable global manufacturer logistics ensuring stable bulk price tiers and timely delivery.
In the landscape of modern pharmaceutical manufacturing, the procurement of key chemical building blocks dictates the efficiency and cost-effectiveness of final API production. 4-Chloro-2-(trifluoroacetyl)aniline Hydrochloride, identified by CAS 173676-59-0, serves as a pivotal pharma intermediate in the synthesis of antiretroviral medications, specifically Efavirenz. For procurement managers and process chemists, understanding the variables influencing the bulk price is essential for maintaining margin integrity while ensuring supply chain resilience. This analysis delves into the technical specifications, manufacturing processes, and commercial tiers associated with sourcing this compound from a reputable global manufacturer.
Technical Specifications and Synthesis Route
The chemical identity of this compound is often referenced interchangeably in technical literature as 2-Amino-5-chloro-2,2,2-trifluoroacetophenone hydrochloride or 1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone hydrochloride. Regardless of the nomenclature, the structural integrity remains consistent, featuring a trifluoroacetyl group ortho to an amino group on a chlorinated benzene ring. The molecular weight typically rests around 260.04 g/mol for the anhydrous hydrochloride salt, though hydrate forms may vary slightly. Maintaining high purity is non-negotiable, as impurities can propagate through subsequent reaction steps, complicating the final API synthesis.
A robust synthesis route is critical for achieving industrial purity levels required by regulatory bodies. The manufacturing process generally involves the acylation of 4-chloro-2-aminoanisole or related precursors followed by hydrolysis and salt formation. Process chemists prioritize routes that minimize hazardous byproducts and maximize reaction yields. When evaluating suppliers, buyers must request a comprehensive Certificate of Analysis (COA) that details not only the assay percentage but also the profile of related substances and residual solvents. A reliable global manufacturer will provide data confirming that the material meets strict specifications for water content, heavy metals, and organic impurities.
Wholesale Pricing Tiers for Bulk Orders
The bulk price of 4-Chloro-2-(trifluoroacetyl)aniline HCl is influenced by raw material availability, energy costs associated with fluorination processes, and the scale of production. Unlike laboratory-scale reagents sold in gram quantities, industrial procurement operates on kilogram and metric ton scales. Pricing structures are typically tiered to reflect the economies of scale achieved during production runs.
| Order Quantity | Pricing Tier Structure | Lead Time | Packaging Standard |
|---|---|---|---|
| 1 kg - 25 kg | Standard Laboratory Rate | 3-5 Days | Double PE Bag / Foil Bag |
| 25 kg - 100 kg | Preferred Pilot Scale | 7-10 Days | Cardboard Drum with PE Liner |
| 100 kg - 500 kg | Commercial Bulk Rate | 10-15 Days | Steel Drum or Custom IBC |
| 500 kg + | Contract Manufacturing | Negotiated | Bulk Bag or Tanker |
Procurement strategies should account for volatility in fluorine chemistry supply chains. Securing a long-term contract often locks in favorable rates, shielding the buyer from market fluctuations. For those seeking specific technical data or commercial quotes, evaluating the 4-Chloro-2-(trifluoroacetyl)aniline Hydrochloride product specifications is the first step toward establishing a supply partnership. Transparency in pricing allows for accurate budgeting during the drug development lifecycle.
Minimum Order Quantities and Logistics
Minimum Order Quantities (MOQ) vary significantly between trading companies and actual production facilities. A true global manufacturer often has higher MOQs for custom synthesis runs but offers lower unit costs. For standard stock items, MOQs may be as low as 1 kg to facilitate pilot plant testing. However, for dedicated production campaigns, MOQs typically start at 25 kg or 50 kg. Logistics play a crucial role in the total landed cost. Since this compound is classified with specific hazard statements (such as H302, H315, H319), proper shipping documentation and packaging are mandatory.
Storage conditions are another logistical consideration. The material should be stored in a cool, dry place, typically recommended at -20°C for long-term stability to prevent degradation of the trifluoroacetyl moiety. Proper inventory management ensures that the chemical building block retains its efficacy until it enters the reactor. NINGBO INNO PHARMCHEM CO.,LTD. emphasizes rigorous quality assurance protocols throughout the storage and shipping phases to guarantee that the industrial purity delivered matches the COA provided at the time of shipment.
Global Shipping Costs and Lead Times
Lead times are a function of production scheduling and customs clearance processes. Domestic shipments within the manufacturing region may arrive within a week, whereas international freight requires careful coordination. Air freight is suitable for urgent, smaller quantities, while sea freight is the standard for bulk orders to optimize costs. Buyers must factor in potential delays due to regulatory inspections, especially when importing pharmaceutical intermediates into strictly regulated markets like the US or EU.
Effective communication with the supplier regarding Incoterms is vital. Whether shipping FOB (Free on Board) or CIF (Cost, Insurance, and Freight), clarity prevents unexpected expenses. A professional supplier will assist with customs documentation, ensuring that the HS codes and safety data sheets align with destination country regulations. This level of service distinguishes a premium partner from generic commodity suppliers.
Conclusion and Supplier Selection
Selecting the right partner for 4-Chloro-2-(trifluoroacetyl)aniline HCl procurement requires a balance of technical capability and commercial reliability. The focus must remain on consistent industrial purity, transparent bulk price structures, and robust logistics. By prioritizing suppliers who demonstrate expertise in the synthesis route and quality assurance, pharmaceutical companies can mitigate risk in their API supply chain.
For organizations requiring high-volume supply and custom synthesis capabilities, partnering with an established entity like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to top-tier manufacturing standards. Their commitment to delivering high purity intermediates supports the global demand for essential antiviral medications. Ultimately, the goal is to secure a supply chain that is both cost-effective and technically sound, enabling seamless progression from intermediate to final therapeutic product.