Intermediates

4-Chloro-2-(trifluoroacetyl)aniline Hydrochloride

  • CAS No.173676-59-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity pharmaceutical intermediate for Efavirenz synthesis. Available in bulk with comprehensive quality documentation.

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Product Technical Details

Product Overview

4-Chloro-2-(trifluoroacetyl)aniline Hydrochloride is a specialized pharmaceutical intermediate characterized by its high chemical stability and precise stoichiometric properties. This compound serves as a critical building block in the multi-step synthesis of advanced antiretroviral medications. Our manufacturing process ensures consistent molecular integrity, making it an ideal choice for research and development teams as well as large-scale production facilities requiring reliable raw materials.

The presence of the trifluoroacetyl group enhances the reactivity profile of the molecule, facilitating efficient coupling reactions during downstream processing. We maintain strict control over the production environment to minimize variability, ensuring that each batch meets the rigorous demands of modern pharmaceutical chemistry.

Technical Specifications

Quality control is paramount in the supply of pharmaceutical intermediates. Each lot undergoes comprehensive analytical testing using high-performance liquid chromatography (HPLC) and other validated methods. The following table outlines the key physical and chemical parameters guaranteed for this product:

ParameterSpecification
CAS Number173676-59-0
Molecular FormulaC8H8Cl2F3NO2
Molecular Weight260.040 g/mol
AppearanceLight yellow crystalline powder
Melting Point156-158°C
Assay (HPLC)≥99.0%
Water Content≤8.0%
SolubilityFreely soluble in Methanol

Impurity profiles are meticulously monitored, with specific limits set for potential byproducts such as p-Chloroaniline and butyl impurities. Our standard test results consistently show total impurities well below the 2.0% threshold, often achieving levels as low as 0.2%.

Industrial Applications

This intermediate is primarily utilized in the synthesis of Efavirenz, a non-nucleoside reverse transcriptase inhibitor. Beyond this specific application, the chemical structure offers versatility for various organic synthesis pathways involving fluorinated aniline derivatives. Pharmaceutical companies leverage this material for process optimization, scale-up studies, and commercial manufacturing of active pharmaceutical ingredients (APIs).

  • Key precursor for antiretroviral drug synthesis
  • Suitable for custom organic synthesis projects
  • Compatible with standard industrial reaction conditions
  • Supports regulatory filing requirements with full documentation

Quality Assurance and Logistics

We operate under stringent quality management systems to ensure product safety and consistency. Every shipment is accompanied by a Certificate of Analysis (COA) detailing batch-specific test results. Packaging is designed to protect the material from moisture and light degradation during transit. Standard packing involves 25 kg drums, though custom packaging solutions are available to meet specific client logistics needs.

Storage recommendations include keeping the material in a cool, ventilated area away from direct sunlight. Our global supply chain capabilities ensure timely delivery to laboratories and manufacturing plants worldwide. For technical inquiries or bulk pricing requests, our sales team is ready to provide detailed support and sample availability information.