Sourcing 4-Chloro-2-methyl-6-trifluoromethylpyrimidine: Bulk Supply & COA
Technical Specifications and Purity Grades for 4-Chloro-2-methyl-6-trifluoromethylpyrimidine
When evaluating 4-Chloro-2-methyl-6-trifluoromethylpyrimidine (CAS 5993-98-6) for pharmaceutical intermediate applications, procurement managers must scrutinize purity grades and technical specifications. This heterocyclic building block, often utilized in API synthesis, demands rigorous quality control. At NINGBO INNO PHARMCHEM, we supply this compound as a seamless drop-in replacement for existing synthesis routes, matching identical technical parameters while offering cost-efficiency and supply chain reliability. Our product is typically offered at 97% purity, with higher purities available upon request. The molecular formula C6H4ClF3N2 and molecular weight 196.56 g/mol are consistent with industry standards. Key physical properties include a predicted boiling point of 171.2±35.0 °C and density of 1.428±0.06 g/cm³. Appearance ranges from colorless to light yellow liquid, a critical parameter for downstream processing. For those requiring industrial purity documentation, our comprehensive COA documentation ensures transparency.
| Parameter | Specification |
|---|---|
| CAS Number | 5993-98-6 |
| Molecular Formula | C6H4ClF3N2 |
| Molecular Weight | 196.56 g/mol |
| Purity (GC) | ≥97% (standard), higher on request |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 171.2±35.0 °C (Predicted) |
| Density | 1.428±0.06 g/cm³ (Predicted) |
| Storage Temperature | Inert atmosphere, -20°C |
Critical COA Parameters and Batch-to-Batch Consistency
Batch-to-batch consistency is non-negotiable in pharmaceutical manufacturing. Our Certificate of Analysis (COA) for 4-Chloro-2-methyl-6-trifluoromethylpyrimidine includes essential parameters such as assay (GC or HPLC), water content (Karl Fischer), and appearance. We also monitor trace impurities that could affect color or reactivity. For instance, residual solvents or halogenated byproducts are tightly controlled. While standard specifications are available, we advise clients to refer to the batch-specific COA for exact numerical data. This compound serves as a pharma intermediate in various synthesis pathways, including as a precursor to 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride, a key intermediate for efavirenz. Our quality assurance protocols align with global manufacturer expectations, ensuring that each shipment meets predefined acceptance criteria. For bulk purchasers, we provide detailed analytical reports and retain samples for future reference.
Industrial-Scale Packaging and Storage Conditions
Proper packaging and storage are critical to maintaining product integrity during transit and warehousing. NINGBO INNO PHARMCHEM offers 4-Chloro-2-methyl-6-trifluoromethylpyrimidine in standard industrial containers: 210L drums and IBC totes, depending on order volume. The compound must be stored under inert atmosphere at -20°C to prevent degradation. Our logistics team ensures that all shipments are accompanied by safety data sheets (SDS) and handling instructions. While we do not claim EU REACH compliance, our packaging meets international physical safety standards. For clients evaluating bulk price options, our competitive tonnage pricing makes us a preferred partner. We also offer custom synthesis for modified specifications, reinforcing our role as a versatile chemical building block supplier.
Non-Standard Behavior: Viscosity and Crystallization at Sub-Zero Temperatures
Field experience reveals that 4-Chloro-2-methyl-6-trifluoromethylpyrimidine exhibits non-standard behavior under extreme conditions. At sub-zero temperatures (below -10°C), the liquid may undergo a viscosity shift, becoming significantly more viscous or even partially crystallizing. This is not a purity defect but a physical characteristic of the compound. To handle this, we recommend gently warming the container to ambient temperature (15-25°C) under inert gas before use. Avoid rapid heating, as localized hotspots could cause decomposition. This insight is crucial for facilities in cold climates or those using cold-chain logistics. Our technical support team can provide detailed protocols for thawing and homogenization, ensuring that the material performs consistently in your synthesis route.
Supply Chain Reliability and Drop-in Replacement Strategy
As a dedicated manufacturer, NINGBO INNO PHARMCHEM prioritizes supply chain resilience. Our 4-Chloro-2-methyl-6-trifluoromethylpyrimidine is positioned as a drop-in replacement for existing sources, eliminating the need for process revalidation. We maintain safety stock and offer flexible delivery schedules to mitigate disruptions. By choosing our product, you gain access to a global manufacturer with a proven track record in heterocyclic intermediates. Our quality assurance framework includes ISO-certified production and rigorous in-process controls. Whether you need gram quantities for R&D or multi-ton lots for commercial production, we scale seamlessly. The compound's role as a 2-Amino-5-chloro-2,2,2-trifluoroacetophenone hydrochloride precursor underscores its importance in antiviral API manufacturing.
Frequently Asked Questions
What is the typical minimum order quantity (MOQ) for 4-Chloro-2-methyl-6-trifluoromethylpyrimidine?
Our standard MOQ is 1 kg for samples and 25 kg for bulk orders. However, we accommodate smaller quantities for R&D purposes. Contact our sales team for tailored quotations.
Can you provide custom synthesis or higher purity grades?
Yes, we offer custom synthesis services to meet specific purity or impurity profiles. Higher purities (e.g., 99%) are achievable with additional processing steps. Please share your target specifications.
What documentation is provided with each shipment?
Each shipment includes a Certificate of Analysis (COA), Safety Data Sheet (SDS), and packing list. Additional documentation (e.g., origin certificate) is available upon request.
How do you ensure batch-to-batch consistency?
We employ validated analytical methods (GC, HPLC, KF) and retain samples from every batch. Our quality management system monitors critical process parameters to minimize variability.
What are the recommended storage conditions for long-term stability?
Store under inert atmosphere (nitrogen or argon) at -20°C. Avoid exposure to moisture and light. Under these conditions, the product remains stable for at least 12 months.
Sourcing and Technical Support
In summary, NINGBO INNO PHARMCHEM delivers high-purity 4-Chloro-2-methyl-6-trifluoromethylpyrimidine with the technical rigor and supply chain reliability that pharmaceutical manufacturers demand. Our drop-in replacement strategy, combined with hands-on field knowledge of non-standard behaviors, ensures a smooth integration into your processes. Ready to optimize your supply chain? Reach out to our logistics team today for comprehensive specifications and tonnage availability.