Industrial Purity Specifications and COA Analysis for 2-(2-Benzylphenyl)Propan-2-Ol
- Strict adherence to GMP standards with assay purity exceeding 98.5% for pharmaceutical intermediates.
- Comprehensive COA documentation covering residual solvents, heavy metals, and crystallographic data.
- Reliable bulk procurement from NINGBO INNO PHARMCHEM CO.,LTD. ensuring supply chain stability.
In the landscape of pharmaceutical intermediate manufacturing, the consistency of chemical specifications is paramount for downstream synthesis success. 2-(2-Benzylphenyl)propan-2-ol (CAS 57732-89-5) serves as a critical tertiary alcohol building block, frequently utilized in the preparation of anthrone derivatives and complex benzhydrol-based active pharmaceutical ingredients (APIs). For procurement managers and process chemists, understanding the Industrial Purity Specifications 2-(2-Benzylphenyl)Propan-2-Ol Coa is essential to mitigate batch-to-batch variability and ensure regulatory compliance.
As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. emphasizes transparency in technical data. This article delineates the critical quality attributes, crystallographic stability, and analytical metrics required for high-grade procurement of this intermediate.
Physicochemical Properties and Crystallographic Stability
The structural integrity of 2-(2-Benzylphenyl)propan-2-ol directly influences its handling characteristics and storage stability. The compound exists as a tertiary alcohol featuring a 2-benzylphenyl substituent, with a molecular formula of C16H18O and a molecular weight of 226.31 g/mol. Crystallographic analysis reveals that the asymmetric unit contains two complete molecules, forming cooperative O—H⋯O hydrogen bonds that connect the molecules into discrete tetramers.
This hydrogen bonding network is critical for bulk stability. The plane defined by the atoms of the participating hydroxyl groups is perpendicular to the crystallographic b axis, contributing to a stable monoclinic crystal system (Space Group P21/c). For industrial applications, the melting point is a key identifier, typically observed between 333–335 K (approx. 60–62°C). Deviations in this range often indicate the presence of isomeric impurities or residual starting materials.
| Parameter | Specification | Test Method |
|---|---|---|
| Chemical Name | 2-(2-Benzylphenyl)propan-2-ol | NMR/MS |
| CAS Number | 57732-89-5 | Registry |
| Molecular Formula | C16H18O | Calculation |
| Molecular Weight | 226.31 g/mol | MS |
| Assay (Purity) | ≥ 98.5% | GC/HPLC |
| Melting Point | 60–62°C (333–335 K) | DSC/Capillary |
| Appearance | White to Off-White Crystalline Solid | Visual |
| Water Content | ≤ 0.5% | Karl Fischer |
Key Purity Metrics: Assay, Residual Solvents, and Heavy Metals
A robust Certificate of Analysis (COA) extends beyond simple assay percentage. For GMP drug synthesis, the manufacturing process must account for trace impurities that could catalyze unwanted side reactions in subsequent steps. The primary metric is the assay purity, where industrial standards demand a minimum of 98.5% via Gas Chromatography (GC) or High-Performance Liquid Chromatography (HPLC).
Residual solvents are a critical concern, particularly if the synthesis route involves Grignard reactions or reductions using organic media. Class 1 solvents must be absent, while Class 2 and 3 solvents must remain within ICH Q3C guidelines. Furthermore, heavy metal content (Pb, As, Cd, Hg) must be controlled to ppm levels to meet pharmacopeial standards for intermediates destined for human therapeutic use.
When sourcing high-purity 2-(2-Benzylphenyl)propan-2-ol, buyers should request full impurity profiles. This includes data on related substances such as unreacted benzyl halides or ketone precursors. The presence of these impurities can significantly lower the yield of the final API, increasing overall production costs.
Meeting Pharmacopeial Standards for GMP Drug Synthesis
The transition from laboratory scale to commercial production requires rigorous validation of the industrial purity parameters. In the context of benzhydrols used for pharmaceutical synthesis, consistency in particle size and polymorphic form can impact dissolution rates during reaction steps. The crystal data indicates a stable packing arrangement, but improper drying or storage can lead to hydrate formation or amorphous content, altering reactivity.
Procurement teams must evaluate suppliers based on their ability to provide consistent bulk price structures without compromising on analytical testing. A reliable partner will offer batch-specific COAs that include chromatograms and spectral data (IR, NMR) upon request. This level of documentation is non-negotiable for audit trails in regulated markets.
Supply Chain and Manufacturing Capabilities
Scalability is the defining factor for industrial intermediates. The production of 2-(2-benzylphenyl)-2-propanol requires precise temperature control and stoichiometry to maintain high yields. NINGBO INNO PHARMCHEM CO.,LTD. operates facilities equipped to handle multi-ton campaigns, ensuring that bulk price advantages are passed to clients without sacrificing quality control.
Alternative synonyms such as (2-Benzyl)-phenyl-2-isopropanol are sometimes used in literature, but CAS 57732-89-5 remains the definitive identifier for procurement. Ensuring the supply chain is resilient against raw material fluctuations is part of the value proposition offered by established manufacturers. Lead times, packaging options (25kg drums or customized containers), and logistics support are integral to the commercial agreement.
Conclusion
The technical integrity of 2-(2-Benzylphenyl)propan-2-ol is foundational to the synthesis of high-value pharmaceutical compounds. By prioritizing detailed COA analysis, understanding crystallographic stability, and partnering with a verified global manufacturer, process chemists can secure a reliable supply chain. NINGBO INNO PHARMCHEM CO.,LTD. remains committed to delivering superior industrial purity and technical support for all bulk inquiries regarding this critical intermediate.