Intermediates

2-(2-Benzylphenyl)propan-2-ol

  • CAS No.57732-89-5
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-(2-benzylphenyl)propan-2-ol (CAS 57732-89-5), a key pharmaceutical intermediate for tricyclic antidepressant synthesis.

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Product Technical Details

Product Overview

2-(2-Benzylphenyl)propan-2-ol is a high-value aromatic tertiary alcohol widely employed as a critical building block in the synthesis of complex pharmaceutical active ingredients. With a molecular formula of C16H18O and a molecular weight of 226.31 g/mol, this compound serves as an essential intermediate in the production of tricyclic antidepressants, particularly Melitracen and its hydrochloride salt.

Specifications

Molecular FormulaC16H18O
Molecular Weight226.31 g/mol
Density1.045 g/cm³
Boiling Point342.7°C at 760 mmHg
Flash Point136.8°C
AppearanceWhite crystalline powder
Assay≥99.0%

Industrial Applications

This compound is primarily utilized in the pharmaceutical industry as a synthetic precursor. Its structural features enable efficient cyclization and functionalization steps during the manufacture of neuroactive therapeutics. Key applications include:

  • Serving as a core intermediate in the multi-step synthesis of Melitracen (CAS 5118-29-6)
  • Facilitating the production of Melitracen hydrochloride (CAS 10563-70-9), a clinically used antidepressant
  • Supporting advanced organic synthesis routes requiring sterically hindered benzylic alcohols

Manufactured under stringent quality control protocols, our 2-(2-benzylphenyl)propan-2-ol meets international pharmacopeial standards for intermediates, ensuring batch-to-batch consistency and reliability for GMP-compliant drug development pipelines.

Handling and Storage

Store in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Keep container tightly closed to prevent moisture absorption and degradation. Standard industrial hygiene practices should be followed during handling.