Industrial Purity 6-Bromocaproyl Chloride COA Specifications and Technical Data
- Critical Specifications: CAS 22809-37-6 requires strict control of free acid and hydrolysis products to ensure reaction yield.
- Safety Profile: Corrosive and moisture-sensitive; requires anhydrous handling and specific PPE during bulk transfer.
- Supply Chain: Reliable global manufacturer status ensures consistent batch-to-batch reproducibility for scale-up.
In the realm of fine chemical manufacturing, the consistency of acyl halides is paramount for downstream reaction efficiency. 6-Bromocaproyl chloride serves as a critical intermediate in the production of pharmaceuticals and agrochemicals. When evaluating suppliers for 6-Bromohexanoyl chloride, procurement managers must look beyond basic CAS identification and scrutinize the Certificate of Analysis (COA) for specific impurity profiles. At NINGBO INNO PHARMCHEM CO.,LTD., we prioritize technical transparency to support complex organic synthesis reagent requirements.
Understanding Industrial Purity Standards and Impurity Profiles
Standard market grades often hover around 97% purity, but for high-value pharmaceutical building block applications, this margin can introduce significant variability. The primary impurities in this molecule typically include the corresponding carboxylic acid (6-bromohexanoic acid) resulting from hydrolysis, and free hydrogen bromide. Even trace amounts of water can trigger exothermic hydrolysis, compromising the industrial purity of the batch.
For large-scale synthesis, maintaining a purity level of 98% or higher is often necessary to minimize downstream purification costs. The presence of free acid can interfere with coupling reactions, reducing overall yield. Therefore, a robust COA should not only list the main assay but also quantify water content and free acidity. Manufacturers employing advanced distillation techniques under reduced pressure can achieve tighter boiling point ranges, ensuring the removal of lower boiling solvents or higher boiling oligomers.
Physical and Chemical Properties
The following table outlines the critical physicochemical parameters expected in a high-quality batch. These values are essential for process engineers designing containment and reaction protocols.
| Parameter | Specification | Technical Significance |
|---|---|---|
| CAS Number | 22809-37-6 | Unique identifier for regulatory compliance. |
| Molecular Formula | C6H10BrClO | Confirms stoichiometry for molar calculations. |
| Molecular Weight | 213.50 g/mol | Critical for precise dosing in reactor charging. |
| Boiling Point | 244.2±0.0 °C at 760 mmHg | Defines distillation cut points during purification. |
| Density | 1.4±0.1 g/cm³ | Required for volumetric transfer calculations. |
| Flash Point | 89.0±22.6 °C | Determines storage class and fire safety protocols. |
| Refractive Index | 1.481 | Quick identity check for incoming raw materials. |
Interpreting COA Specifications and Safety Data
Beyond physical constants, the safety data associated with this bromoacyl chloride derivative dictates strict handling procedures. The substance is classified under Hazard Class 8 (Corrosive) with UN number 3265. Safety phrases indicate severe risks upon contact with skin or eyes (H314) and potential respiratory irritation (H335). Consequently, the manufacturing process must occur in closed systems with adequate ventilation.
A comprehensive COA will also reference the HS Code, typically 29159080 or 2915900090, depending on the specific export jurisdiction. This classification affects tariff rates and inspection conditions. For importers, verifying that the supplier provides accurate documentation matching these codes is vital to prevent customs delays. Furthermore, the packaging group (PG II) indicates the level of danger presented by the goods during transport, necessitating robust drum or IBC containment.
Synthesis Route and Downstream Applications
This compound functions primarily as an alkylating agent in organic synthesis. The synthesis route typically involves the chlorination of 6-bromohexanoic acid using reagents such as thionyl chloride or oxalyl chloride. The efficiency of this conversion directly impacts the color and stability of the final product. Pale yellow to colorless liquids are preferred, as darkening often indicates decomposition or iron contamination.
Downstream, this intermediate is utilized to introduce a bromoalkyl chain into various molecular scaffolds. It is frequently employed in the preparation of quaternary ammonium compounds and specialized polymers. The terminal bromine atom offers a reactive handle for nucleophilic substitution, allowing chemists to extend carbon chains or introduce nitrogen-containing functional groups. Consistency in the 6-Bromohexanoic acid chloride supply ensures that these subsequent reactions proceed with predictable kinetics.
Batch Consistency for Large Scale Synthesis
For contract manufacturing organizations (CMOs) and bulk buyers, batch-to-batch consistency is more valuable than spot pricing. Variations in purity can force process chemists to re-optimize reaction conditions, leading to costly downtime. A reliable global manufacturer will implement strict Quality Control (QC) protocols, including Gas Chromatography (GC) and Karl Fischer titration for every production lot.
When negotiating bulk price agreements, buyers should request historical COA data to verify stability over time. NINGBO INNO PHARMCHEM CO.,LTD. maintains rigorous documentation standards to support audit requirements for regulated industries. By securing a supply chain partner capable of delivering consistent industrial purity, companies can mitigate the risk of production failures and ensure timely delivery of final active pharmaceutical ingredients.
In conclusion, sourcing 6-Bromocaproyl Chloride requires a detailed understanding of technical specifications beyond the CAS number. Prioritizing suppliers who provide transparent COA data, adhere to safety regulations, and maintain high purity standards is essential for successful scale-up. Whether for research or commercial production, the quality of this acyl chloride directly influences the efficiency and safety of the entire synthetic pathway.