4-Bromoisobenzofuran-1,3-Dione Bulk Price 2026: Industrial Trends & Procurement Guide
- 2026 bulk pricing for 4-Bromoisobenzofuran-1,3-dione is shaped by raw material volatility, scale of synthesis, and global logistics.
- Industrial purity (≥98%) and full analytical documentation (COA, HPLC, NMR) are critical for pharmaceutical and fine chemical applications.
- NINGBO INNO PHARMCHEM CO.,LTD. offers scalable manufacturing with competitive FOB China rates and short lead times for multi-kilogram orders.
As the pharmaceutical and agrochemical sectors intensify R&D into novel heterocyclic scaffolds, demand for 4-Bromoisobenzofuran-1,3-dione (CAS 82-73-5)—also widely referenced as 3-Bromophthalic anhydride—continues to rise. This brominated aromatic anhydride serves as a pivotal building block in cross-coupling reactions, particularly for constructing kinase inhibitors, PROTAC degraders, and advanced intermediates in oncology pipelines. With 2026 approaching, procurement teams are actively forecasting bulk price trajectories based on synthesis complexity, regulatory compliance, and supply chain resilience.
Global Bulk Pricing Trends for 4-Bromoisobenzofuran-1,3-Dione in 2026
The bulk price of 4-Bromoisobenzofuran-1,3-dione in 2026 is expected to remain stable within a narrow band, assuming no major disruptions in bromine feedstock markets or energy costs in key manufacturing hubs. Current indicative pricing (Q2 2024–Q1 2025) for industrial-grade material (≥98% purity) ranges from USD 850 to USD 1,200 per kilogram, depending on order volume, packaging, and analytical validation depth. However, prices for pharma-grade batches (≥99% by HPLC, with full COA and spectral data) can command a 15–25% premium due to stringent quality control protocols.
When sourcing high-purity 4-Bromoisobenzofuran-1,3-dione, buyers should prioritize suppliers with vertically integrated manufacturing processes that minimize third-party dependency and ensure batch-to-batch consistency—critical for GMP-aligned drug development.
Factors Influencing Industrial-Grade Pricing
Several technical and commercial variables directly impact the final bulk price quoted to B2B clients:
1. Purity and Analytical Validation
Industrial purity standards vary by application. While research labs may accept 97% purity, API manufacturers typically require ≥99% with comprehensive impurity profiling via HPLC, LC-MS, and 1H/13C NMR. Full COA documentation—including residual solvent, heavy metal, and water content—is non-negotiable for regulated use.
2. Synthesis Route Efficiency
The dominant synthesis route involves electrophilic bromination of phthalic anhydride under controlled conditions, followed by crystallization. Yields above 85% are achievable at scale, but side-product formation (e.g., dibrominated impurities) necessitates rigorous purification. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. optimize this pathway to reduce waste and enhance cost-efficiency without compromising purity.
3. Order Volume and Logistics
Pricing scales favorably with volume. Orders exceeding 10 kg often qualify for tiered discounts, while container-load shipments (≥100 kg) benefit from consolidated freight and reduced per-unit handling costs. Temperature-controlled transport (ambient or dry ice, as required) also factors into landed costs, especially for moisture-sensitive anhydrides.
How to Request Competitive Quotations from Verified Manufacturers
To secure accurate and actionable pricing for 2026 delivery, procurement specialists should provide vendors with precise specifications:
- Target purity (e.g., 98% min by HPLC)
- Required analytical data (NMR, LC-MS, elemental analysis)
- Intended application (R&D, pilot-scale, or commercial API synthesis)
- Annual volume forecast and preferred packaging (glass, HDPE, or fiber drums)
Reputable global manufacturers will respond with itemized quotes including FOB terms, lead time (typically 2–4 weeks for bulk), and regulatory support documents (SDS, REACH, TSCA). NINGBO INNO PHARMCHEM CO.,LTD., as a certified ISO 9001 producer with extensive experience in halogenated aromatics, provides end-to-end traceability and rapid technical response for complex inquiries.
Technical Specifications & Commercial Comparison (2026 Outlook)
| Parameter | Standard Industrial Grade | Pharma-Grade (GMP-Aligned) |
|---|---|---|
| CAS Number | 82-73-5 | |
| Molecular Formula | C8H3BrO3 | |
| Molecular Weight | 227.01 g/mol | |
| Purity (HPLC) | ≥98% | ≥99% |
| Analytical Package | HPLC, FTIR, SDS | HPLC, LC-MS, 1H/13C NMR, CHNS, COA |
| Bulk Price Range (2026 Est.) | USD 850 – 1,050/kg | USD 1,050 – 1,350/kg |
| Min. Order Quantity | 1 kg | 5 kg |
| Lead Time | 2–3 weeks | 3–4 weeks (with full QC) |
For companies scaling up preclinical candidates or optimizing synthetic routes, securing a reliable source of high-integrity 4-Bromoisobenzofuran-1,3-dione is not merely a procurement task—it’s a strategic enabler. With its robust infrastructure and focus on halogenated specialty intermediates, NINGBO INNO PHARMCHEM CO.,LTD. stands as a premier partner for global innovators seeking both technical excellence and commercial agility in 2026 and beyond.