4-Bromo-3-(Trifluoromethyl)Aniline Bulk Price 2026: Market Outlook & Technical Procurement Guide
- Projected 2026 bulk prices for 4-Bromo-3-(trifluoromethyl)aniline reflect stable demand in ADC and kinase inhibitor synthesis.
- Industrial purity (≥98.5%) and scalable synthesis routes directly impact cost efficiency at multi-kilogram volumes.
- NINGBO INNO PHARMCHEM CO.,LTD. offers verified COA documentation and flexible logistics for global B2B buyers.
As pharmaceutical and agrochemical R&D intensifies around fluorinated aromatic scaffolds, 4-Bromo-3-(trifluoromethyl)aniline (CAS 393-36-2) has emerged as a critical building block for targeted therapies—including antibody-drug conjugates (ADCs), JAK/STAT modulators, and PI3K/Akt/mTOR pathway inhibitors. With 2026 procurement cycles approaching, industrial buyers are prioritizing not only competitive bulk pricing but also supply chain reliability, batch-to-batch consistency, and regulatory documentation. This article analyzes current market dynamics, technical specifications, and strategic sourcing considerations for this high-value intermediate.
Current Bulk Pricing Trends for CAS 393-36-2 in Global Markets
While small-scale laboratory listings (e.g., 250 mg units) may cite prices around $59 USD, these figures are irrelevant to industrial procurement. Bulk quotations for 4-bromo-3-trifluoromethyl-aniline—typically ordered in 1 kg to 100+ kg quantities—are governed by economies of scale, raw material availability, and regional regulatory compliance. As of Q2 2025, FOB China prices for ≥98.5% purity material range between $1,200–$1,800 per kg, with significant discounts available for annual contracts exceeding 500 kg.
Notably, the compound is also referenced under alternative nomenclature such as 5-amino-2-bromobenzotrifluoride or 3-trifluoromethyl-4-bromoaniline, which can affect database matching during supplier vetting. Buyers must confirm structural identity via CAS 393-36-2 and request full spectral validation (NMR, HPLC, GC-MS) alongside Certificates of Analysis (COA).
Factors Influencing 2026 Wholesale Costs: Purity, Volume, and Logistics
Three primary variables will shape the bulk price trajectory of 4-Amino-1-bromo-2-(trifluoromethyl)benzene through 2026:
- Synthesis Route Efficiency: The dominant industrial method involves regioselective bromination of 3-(trifluoromethyl)nitrobenzene followed by catalytic hydrogenation. Optimized routes minimize di-brominated impurities and reduce palladium catalyst loading—directly lowering COGS.
- Purity Thresholds: Pharmaceutical applications demand ≥98.5% purity (HPLC area%), with strict limits on residual solvents (<500 ppm) and heavy metals (<10 ppm). Higher purity commands premium pricing but reduces downstream purification costs.
- Geopolitical & Logistics Factors: Export controls on brominated aromatics, shipping container availability, and port congestion in key Asian hubs may introduce 5–12% cost volatility in 2026.
When sourcing high-purity 4-Bromo-3-(trifluoromethyl)aniline, buyers should prioritize suppliers with ISO 9001-certified manufacturing processes and in-house analytical capabilities to ensure reproducibility.
Technical Specifications & Quality Benchmarks
| Parameter | Specification |
|---|---|
| CAS Number | 393-36-2 |
| Molecular Formula | C₇H₅BrF₃N |
| Molecular Weight | 240.02 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98.5% |
| Residual Solvents | Meets ICH Q3C guidelines |
| Packaging | 25 kg fiber drums with double PE liners |
How to Request Custom Quotes from Verified Industrial Suppliers
For accurate 2026 bulk pricing, B2B buyers should submit detailed RFQs specifying:
- Required annual volume (e.g., 200 kg/year)
- Target purity and impurity profile
- Intended application (e.g., ADC payload synthesis)
- Preferred Incoterms (FOB Shanghai, CIF Rotterdam, etc.)
- Regulatory documentation needs (DMF, GMP statement, REACH)
As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. provides end-to-end process development, kilo-lab to multi-ton production capacity, and rapid sample dispatch (7–10 days). Their vertically integrated manufacturing process ensures consistent quality for 4-bromo-3-(trifluoromethyl)aniline, with real-time batch tracking and full traceability from raw materials to finished API intermediates.
With rising demand in oncology and immunology pipelines, securing a reliable supply agreement before Q4 2025 is advisable to lock in favorable 2026 rates. NINGBO INNO PHARMCHEM CO.,LTD. currently offers tiered pricing for long-term partners, including dedicated inventory allocation and quarterly quality audits.