4-Bromo-3-(trifluoromethyl)aniline
- CAS No.393-36-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Bromo-3-(trifluoromethyl)aniline (CAS 393-36-2), a key fluorinated aromatic intermediate for pharmaceutical and agrochemical synthesis.
Request Bulk PricingProduct Technical Details
Product Overview
4-Bromo-3-(trifluoromethyl)aniline is a high-value fluorinated aromatic amine widely employed as a critical building block in the synthesis of advanced organic molecules. With its unique combination of bromo and trifluoromethyl substituents adjacent to the amino group, this compound offers exceptional reactivity and selectivity in cross-coupling reactions, making it indispensable in modern medicinal chemistry and crop protection agent development.
Specifications
| Molecular Formula | C7H5BrF3N |
|---|---|
| Molecular Weight | 240.02 g/mol |
| CAS Number | 393-36-2 |
| Appearance | White powder |
| Purity | ≥98.0% |
| Melting Point | 47–49 °C (lit.) |
| Boiling Point | 81–84 °C at 0.5 mm Hg (lit.) |
| Density | 1.697 g/cm³ |
| Refractive Index | 1.522 |
| Flash Point | >230 °F |
Industrial Applications
This compound serves primarily as a versatile synthetic intermediate in the production of complex pharmaceutical APIs and specialty agrochemicals. Its structural features enable efficient functionalization via palladium-catalyzed couplings (e.g., Suzuki, Buchwald-Hartwig), nucleophilic aromatic substitution, and diazotization pathways. Key application areas include:
- Construction of fluorinated heterocyclic scaffolds for kinase inhibitors and CNS-targeted therapeutics
- Synthesis of novel herbicides and fungicides requiring enhanced metabolic stability
- Preparation of liquid crystal monomers and electronic materials
As a non-application-ready chemical, it is intended exclusively for industrial-scale synthesis and R&D use under controlled laboratory or manufacturing conditions.
Handling and Storage
Store in a tightly sealed container in a cool, dry, and well-ventilated area away from oxidizing agents and strong acids. Use appropriate personal protective equipment during handling. Supplied in 25 kg drums or multi-layer bags with full documentation including Certificate of Analysis (COA).
