Industrial Synthesis Route 4-(Pyridin-2-Ylcarbamoyl)Phenyl Boronic Acid
The global pharmaceutical landscape increasingly relies on robust supply chains for critical kinase inhibitor intermediate materials. As demand scales for targeted therapies, procurement teams prioritize vendors capable of delivering consistent quality across multi kilogram batches. NINGBO INNO PHARMCHEM CO.,LTD. maintains a stable supply of [4-(pyridin-2-ylcarbamoyl)phenyl]boronic acid to mitigate supply chain risks associated with complex boronic acid derivatives. This overview addresses the technical requirements for scaling production while maintaining strict analytical standards.
Detailed Chemical Synthesis Route and Reaction Mechanism
The production of 4-(Pyridin-2-yl)aminocarbonylphenylboronic acid typically begins with the lithiation of 4-bromo-N-(pyridin-2-yl)benzamide. Reaction conditions require precise temperature control, often cooling the mixture to -75°C before adding n-butyl lithium. Subsequent treatment with triisopropyl borate facilitates the formation of the boronate ester, followed by acidic hydrolysis to yield the free boronic acid. This pyridinyl boronic acid derivative requires advanced purification techniques utilizing orthophosphoric acid treatment to achieve high quality. This step is critical for reducing the desbromo impurity to less than 0.1% as measured by HPLC. Such refinement ensures the material serves effectively as an acalabrutinib building block without compromising downstream coupling yields.
Technical Specifications and Analytical Methods
| Parameter | Specification |
|---|---|
| CAS Number | 850568-25-1 |
| Molecular Formula | C12H11BN2O3 |
| Molecular Weight | 242.04 g/mol |
| Purity (HPLC) | ≥ 98.0% (Customizable to 99.5%) |
| Desbromo Impurity | ≤ 0.1% |
| Analysis Method | HPLC, NMR, KF |
Strict Quality Assurance (QA) Workflow and COA Verification Process
Every batch undergoes rigorous verification to ensure the COA matches physical shipment data. Our quality team validates identity and potency using orthogonal analytical methods before release. Procurement officers can review historical stability data to confirm shelf-life expectations under standard storage conditions. For detailed cost analysis and supply projections, refer to our report on 4-(Pyridin-2-Yl)Aminocarbonylphenylboronic Acid Bulk Price Manufacturer 2026. NINGBO INNO PHARMCHEM CO.,LTD. commits to full transparency regarding manufacturing process changes that could impact regulatory filings.
Reliable sourcing of this chemical is essential for maintaining production schedules in oncology drug manufacturing. We combine technical expertise with logistical reliability to support your R&D and commercial needs. For custom synthesis requirements or to validate our drop-in replacement data, consult with our process engineers directly.