1-Fluoro-4-Nitrobenzene Manufacturing Process & Industrial Purity
Procurement managers and R&D chemists frequently face challenges securing consistent industrial purity levels for critical intermediates. Supply chain volatility often compromises batch-to-batch reproducibility, impacting downstream synthesis efficiency and regulatory compliance.
Detailed Chemical Synthesis Route and Reaction Mechanism
The manufacturing process for 1-Fluoro-4-nitrobenzene typically employs a halogen exchange fluorination method. This involves reacting p-nitrochlorobenzene with anhydrous potassium fluoride in a high-boiling organic solvent such as dimethyl sulfoxide. A catalyst, often a crown ether like 18-crown-6, enhances fluoride ion activity by complexing with potassium ions. The reaction proceeds via nucleophilic aromatic substitution, where the electron-withdrawing nitro group stabilizes the negative ion intermediate, facilitating the displacement of the chlorine atom by fluorine. Temperature control between 150-200°C is critical to balance reaction rate and yield while minimizing byproduct formation. This robust synthesis route ensures the production of a reliable chemical building block for pharmaceutical and material science applications.
Technical Specifications and Analytical Methods
Quality assurance relies on rigorous analytical verification. Below are the standard technical parameters for commercial grades. Verification via GC and FTIR ensures structural conformity and assay accuracy.
| Parameter | Specification |
|---|---|
| CAS Number | 350-46-9 |
| Chemical Name | 4-Fluoronitrobenzene / 1-Fluoro-4-nitrobenzene |
| Molecular Formula | C6H4FNO2 |
| Molecular Weight | 141.10 g/mol |
| Purity (GC) | ≥ 99.0% (Industrial Grade) |
| Melting Point | 21-24°C |
| Boiling Point | 214-216°C |
| Density | 1.33 g/mL at 25°C |
| Appearance | Colorless to Light Yellow Liquid or Solid |
| Identification | Conforms to Structure (FTIR) |
Factory-Direct Bulk Pricing Advantages and Supply Chain Stability
Securing a stable supply of 4-Nitrofluorobenzene requires a partner with vertical integration capabilities. NINGBO INNO PHARMCHEM CO.,LTD. provides factory-direct access, eliminating intermediary markups and ensuring competitive bulk price structures for large-scale procurement. Our production facilities maintain strict inventory controls to guarantee availability regardless of market fluctuations. Every shipment is accompanied by comprehensive documentation, including a batch-specific COA and SDS, to facilitate seamless regulatory clearance and quality audits. By partnering with a global manufacturer like NINGBO INNO PHARMCHEM CO.,LTD., organizations mitigate risk and optimize their raw material sourcing strategy for long-term projects.
Reliable access to high-purity intermediates is essential for maintaining production schedules and product efficacy. Our commitment to quality control and logistical efficiency ensures that your operations remain uninterrupted. To request a batch-specific COA, SDS, or secure a bulk pricing quote, please contact our technical sales team.