Intermediates

4-Fluoronitrobenzene

  • CAS No.350-46-9
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Fluoronitrobenzene (CAS 350-46-9) designed for advanced organic synthesis and pharmaceutical intermediate production. Reliable bulk supply with strict quality control.

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Product Technical Details

Product Overview

4-Fluoronitrobenzene is a vital fluorinated aromatic compound widely recognized for its significant role in modern organic synthesis and chemical manufacturing. As a key building block, this substance serves as a foundational precursor in the development of various pharmaceutical agents, agrochemical products, and specialized functional materials. The unique combination of a nitro group and a fluorine atom on the benzene ring provides distinct reactivity profiles, enabling chemists to perform selective nucleophilic aromatic substitution reactions with high efficiency. Our facility produces this intermediate under stringent quality management systems to ensure consistency and reliability for downstream industrial applications.

Chemical Properties and Structure

The molecular structure of 4-Fluoronitrobenzene features a benzene ring substituted with a fluorine atom at the para position relative to a nitro group. This arrangement enhances the electrophilic character of the aromatic ring, making it highly susceptible to displacement reactions by nucleophiles. The fluorine atom acts as an excellent leaving group in specific conditions, while the nitro group can be reduced to an amine, offering versatile synthetic pathways. The compound typically presents as a light yellow transparent liquid with a characteristic odor. Its physical stability and solubility profile make it suitable for various reaction mediums, including polar aprotic solvents commonly used in fine chemical synthesis.

Technical Specifications

ParameterSpecification
CAS Number350-46-9
Molecular FormulaC6H4FNO2
Molecular Weight141.10 g/mol
AppearanceLight yellow transparent liquid
Purity (Assay)≥99.5%
Moisture Content≤0.2%
Density1.33 g/cm3
Boiling Point205°C
Melting Point21°C
Flash Point182°F

Industrial Applications

This chemical intermediate is extensively utilized across multiple high-value sectors. In the pharmaceutical industry, it is employed in the synthesis of kinase inhibitors, antibacterial agents, and other therapeutic compounds where fluorine incorporation enhances metabolic stability and bioavailability. In agrochemicals, it serves as a precursor for herbicides and pesticides, contributing to crop protection solutions. Additionally, it finds application in the production of dyes, pigments, and polymeric materials where specific electronic properties are required. Our manufacturing process supports custom synthesis routes to meet specific project requirements for research and development teams.

Quality Assurance and Safety

We adhere to rigorous quality control protocols to guarantee the integrity of every batch. Each production lot undergoes comprehensive analysis using advanced chromatography and spectroscopy methods to verify purity and identity. A Certificate of Analysis (COA) is provided with every shipment to ensure transparency and compliance with international standards. Regarding safety, this compound should be handled in a well-ventilated environment with appropriate personal protective equipment. It must be stored in a cool, dry place away from incompatible materials such as strong oxidizing agents. Proper containment prevents environmental release and ensures workplace safety during handling and transfer operations.

Packaging and Logistics

To maintain product integrity during transit, 4-Fluoronitrobenzene is packaged in secure 200 kg drums designed to prevent leakage and contamination. We also offer flexible packaging solutions tailored to specific customer requirements and logistical constraints. Our global supply chain network ensures timely delivery to manufacturers and research institutions worldwide. Competitive bulk pricing is available for large-scale orders, supported by our commitment to being a reliable global manufacturer. Contact our technical sales team for detailed information on lead times, shipping documentation, and custom formulation support.