5-Bromo-2-Iodopyridine Synthesis Route & Supply Guide
The global demand for high-performance heterocyclic compounds continues to surge within the pharmaceutical and agrochemical sectors. As a critical halogenated pyridine derivative, this substance serves as a versatile organic building block for complex molecule assembly. Procurement teams face challenges regarding batch-to-batch consistency and industrial purity levels required for scale-up. NINGBO INNO PHARMCHEM CO.,LTD. addresses these supply chain vulnerabilities by maintaining robust inventory levels and transparent manufacturing protocols.
Detailed Chemical Synthesis Route and Reaction Mechanism
The preferred synthesis route typically involves the diazotization of 2-amino-5-bromopyridine followed by iodination using potassium iodide. This method ensures high regioselectivity, minimizing isomeric impurities such as 3-Bromo-6-iodopyridine. The reaction mechanism relies on the formation of a diazonium salt intermediate, which undergoes nucleophilic substitution with iodide ions under controlled acidic conditions. This process is vital for producing a reliable cross-coupling reagent suitable for palladium-catalyzed reactions like Suzuki-Miyaura or Stille couplings. Recent literature highlights the conversion of this material into 5-Bromo-2-pyridylzinc reagents under mild conditions, facilitating smooth transmetalation for diverse electrophiles.
Technical Specifications and Analytical Methods
Quality control relies on rigorous testing parameters to ensure suitability as a pharmaceutical intermediate. The following table outlines the standard specifications for commercial grades.
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 223463-13-6 | Verification |
| Purity (HPLC) | > 98.0% | Area Normalization |
| Appearance | Off-white to Pale Yellow Solid | Visual Inspection |
| Water Content | < 0.5% | Karl Fischer |
| Isomeric Impurity | < 0.1% | GC-MS / NMR |
Strict Quality Assurance (QA) Workflow and COA Verification Process
Every batch undergoes a multi-stage verification process before release. Our quality assurance team validates the COA against internal standards and third-party audits to guarantee data integrity. NINGBO INNO PHARMCHEM CO.,LTD. implements strict traceability measures, allowing clients to track production history from raw material sourcing to final packaging. This diligence ensures that the bulk price reflects genuine value without compromising on safety or compositional accuracy.
For researchers requiring detailed documentation or custom packaging solutions for 5-Bromo-2-iodopyridine, our technical support team is prepared to assist with immediate requirements.
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