N-(3-Chloropropyl)Dibutylamine Bulk Price 2026: Market Trends & Procurement Guide
- Current bulk pricing for high-purity N-(3-chloropropyl)dibutylamine ranges from $90–$320/kg depending on volume, purity, and supplier reliability.
- As a key chemical intermediate in the synthesis of antiarrhythmic drugs like dronedarone, demand is driven by pharmaceutical API production scale-up in 2026.
- Industrial purity (≥98%), consistent COA documentation, and robust synthesis routes are critical for B2B buyers evaluating long-term supply partnerships.
N-(3-Chloropropyl)dibutylamine (CAS 36421-15-5), also known as N,N-Dibutyl-3-chloro-1-propanamine or Dibutyl(3-chloropropyl)amine, is a vital aliphatic tertiary amine widely employed as a pharmaceutical intermediate. Its primary application lies in the multi-step synthesis of dronedarone hydrochloride, a Class III antiarrhythmic agent. With rising global demand for cardiovascular therapeutics, procurement professionals and process chemists are increasingly focused on securing stable, cost-effective bulk supplies of this compound heading into 2026.
Current Bulk Pricing Trends for N-(3-Chloropropyl)Dibutylamine
Historical data from 2021–2025 indicates significant price variability based on packaging size, purity grade, and regional supply chain dynamics. Small-scale research quantities (1–10 g) have been quoted between $21–$165, while 100 g lots typically range from $79–$195. However, these figures are not representative of true bulk procurement economics. For commercial-scale orders (≥1 kg), prices consolidate significantly due to economies of scale in manufacturing and logistics.
In 2026, verified manufacturers offering industrial-grade material (≥98% purity) are expected to quote between $90–$130 per kilogram for multi-kilogram orders, with further reductions available under annual supply agreements. When sourcing high-purity N-(3-chloropropyl)dibutylamine, buyers should prioritize suppliers capable of providing full analytical documentation, including GC/HPLC chromatograms, NMR validation, and up-to-date Certificates of Analysis (COA).
Factors Influencing Global Wholesale Costs in 2026
Several technical and market-driven variables will shape the 2026 bulk price landscape for this chemical intermediate:
- Synthesis Route Efficiency: The standard industrial method involves nucleophilic substitution of 1-chloro-3-bromopropane with dibutylamine under controlled conditions. Optimized routes that minimize side products (e.g., quaternary ammonium salts) directly impact yield (>85% achievable) and final cost.
- Raw Material Volatility: Fluctuations in butylamine and 3-chloro-1-propanol derivatives—key precursors—affect input costs. Geopolitical stability in major petrochemical-producing regions plays a role here.
- Purity Requirements: Pharmaceutical applications demand ≥98% purity with strict limits on residual solvents and heavy metals. Suppliers investing in advanced distillation and crystallization infrastructure can meet these specs consistently without inflating prices.
- Regulatory Compliance: REACH, TSCA, and ICH Q7 alignment adds compliance overhead but ensures seamless import/export. Reputable global manufacturers absorb these costs efficiently, avoiding last-minute shipment delays.
Technical Profile & Handling Considerations
N-(3-Chloropropyl)dibutylamine (molecular formula C11H24ClN, MW: 205.77) is a pale yellow liquid at room temperature with a predicted density of 0.899 ± 0.06 g/cm³. It exhibits a boiling point of 118–130 °C at 25 Torr and a pKa of ~9.39, reflecting its basic amine character. Due to its reactivity and moisture sensitivity, it must be stored sealed under dry conditions at 2–8 °C. Safety data sheets classify it with hazard statements H302 (harmful if swallowed), H315 (causes skin irritation), and H319 (causes eye irritation), necessitating standard PPE during handling.
How to Request Custom Quotes from Verified Manufacturers
For B2B buyers seeking reliable, scalable supply of 3-Chloropropyl dibutylamine or its systematic synonym N-Butyl-N-(3-chloropropyl)butan-1-amine, the following steps ensure optimal procurement outcomes:
- Specify Technical Requirements: Clearly define needed purity (e.g., 98% vs. 99%), residual solvent limits, packaging (drums vs. IBC totes), and analytical support (COA, GC traces).
- Request Batch-Specific Documentation: Leading manufacturers provide lot-specific COAs, ensuring traceability and regulatory readiness for GMP environments.
- Evaluate Synthesis Scalability: Confirm the supplier’s capacity to scale from pilot (10–100 kg) to commercial (tonnage) volumes without compromising quality or timeline.
NINGBO INNO PHARMCHEM CO.,LTD.—a top-tier Chinese manufacturer—offers competitively priced, high-purity N-(3-chloropropyl)dibutylamine with full regulatory documentation and flexible bulk packaging. Our vertically integrated synthesis route ensures consistent industrial purity and rapid turnaround for global clients.
Bulk Pricing Reference Table (2026 Estimate)
| Package Size | Purity | Estimated Price Range (USD) | Typical Lead Time |
|---|---|---|---|
| 100 g | ≥98% | $90 – $110 | 1–2 weeks |
| 1 kg | ≥98% | $85 – $100 | 2–3 weeks |
| 10 kg+ | ≥98% | $75 – $90 | Negotiable |
| Tonnage Orders | ≥98.5% | Custom Quote | 4–8 weeks |
Note: Prices are indicative and subject to raw material markets, order volume, and shipping terms (FOB vs. CIF). All batches include comprehensive COA and comply with international safety standards.
As the pharmaceutical industry intensifies production of complex APIs like dronedarone, securing a dependable source of high-quality N-(3-chloropropyl)dibutylamine is no longer optional—it’s strategic. Partnering with a manufacturer that controls the entire synthesis route, from precursor to final distillation, ensures both cost efficiency and supply chain resilience through 2026 and beyond.