Bulk Price Of (S)-1-Boc-3-Hydroxypiperidine 2026: Market Analysis and Procurement Guide
- Market Pricing: Bulk procurement costs vary significantly based on volume, with laboratory-scale prices ranging from $5 to $20 per gram, while industrial contracts offer substantial discounts.
- Technical Specs: Critical quality attributes include CAS 143900-44-1, molecular weight 201.26, and typical purity standards exceeding 97% with defined optical activity.
- Sourcing Strategy: Partnering with a reliable global manufacturer ensures consistent supply chains, validated COA documentation, and optimized synthesis routes for scale-up.
Current Bulk Pricing Trends for (S)-1-Boc-3-hydroxypiperidine in 2026
The pharmaceutical intermediate market is experiencing dynamic shifts as demand for kinase inhibitors continues to rise. For procurement managers and synthetic chemists, understanding the bulk price trajectory of key chiral building blocks is essential for budget forecasting. Market data indicates a wide disparity between research-grade and production-grade pricing. Small-scale packages (1g to 10g) often command premiums between $5 and $20 per unit due to packaging and handling overheads. However, as volume increases to the 100g or kilogram scale, the cost per gram decreases dramatically.
In the 2026 landscape, suppliers are adjusting pricing models to reflect raw material availability and energy costs associated with the manufacturing process. While some niche suppliers list prices as high as $1300 for specialized salt forms or small batches, established supply chains offer competitive rates for standard free base forms. When evaluating suppliers for large-scale production of (S)-1-Boc-3-hydroxypiperidine, buyers should prioritize vendors who demonstrate capacity for multi-kilogram campaigns without compromising enantiomeric excess. The economic viability of downstream synthesis, particularly for drugs like Ibrutinib, relies heavily on securing these intermediates at stable price points.
Factors Influencing Industrial-Scale Pricing and Purity
The cost structure of chiral piperidine derivatives is intrinsically linked to the complexity of the synthesis route. Achieving high optical purity requires precise control during the resolution or asymmetric synthesis stages. Common specifications for this intermediate include a melting point between 34-40 °C and a boiling point of approximately 292.3 °C. Deviations in these physical properties often indicate impurities that can affect downstream coupling reactions.
Industrial buyers must scrutinize the industrial purity levels offered by potential partners. Standard commercial grades typically guarantee 97% to 98% purity by HPLC. However, for GMP-grade applications, stricter controls on residual solvents and heavy metals are necessary. The chemical formula C10H19NO3 and molecular weight of 201.26 dictate the stoichiometry used in process chemistry. Any variance in assay value directly impacts the yield of the final active pharmaceutical ingredient (API).
Furthermore, the stability of the Boc (tert-butoxycarbonyl) protecting group under various storage conditions influences logistics costs. The compound should be kept in a dark place, sealed in dry conditions at room temperature. Suppliers who provide robust packaging to prevent hydrolysis during transit add value that justifies a marginally higher unit cost. Requesting a comprehensive COA (Certificate of Analysis) is standard practice to verify optical activity, typically reported as [α]22/D +10.0° (c = 1 in chloroform).
Technical Specifications and Physical Properties
To facilitate accurate quality control during incoming inspection, procurement teams should reference the following standard physical and chemical data. These parameters are critical for validating shipments against the purchased order specifications.
| Property | Specification |
|---|---|
| CAS Number | 143900-44-1 |
| Molecular Formula | C10H19NO3 |
| Molecular Weight | 201.26 g/mol |
| EINECS | 1308068-626-2 |
| MDL Number | MFCD06659041 |
| Melting Point | 34-40 °C |
| Boiling Point | 292.3±33.0 °C (Predicted) |
| Density | 1.107±0.06 g/cm3 (Predicted) |
| Flash Point | 110 °C |
| Optical Activity | [α]22/D +10.0°, c = 1 in chloroform |
| Appearance | White to tan powder or crystalline powder |
| Solubility | Soluble in methanol |
How to Request Competitive Quotes from Global Manufacturers
Securing the best commercial terms requires a strategic approach to vendor qualification. When contacting a global manufacturer, it is advisable to provide detailed project timelines and volume forecasts. This allows the supplier to allocate reactor capacity efficiently, often resulting in better pricing tiers. Buyers should explicitly inquire about the synonym (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine or (S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine to ensure the vendor understands the specific stereochemistry required, as the (R)-enantiomer may be priced differently due to demand variations.
Reliability is as crucial as cost. NINGBO INNO PHARMCHEM CO.,LTD. stands out as a premier partner for organizations requiring high-volume supply chains with rigorous quality assurance. By leveraging their extensive experience in pharmaceutical intermediates, clients can mitigate the risk of supply chain disruptions. Effective communication regarding packaging requirements—whether 25g, 100g, or multi-kilogram drums—ensures that the material arrives in optimal condition for immediate use in synthesis.
In conclusion, the 2026 market for this chiral intermediate offers opportunities for cost optimization through strategic bulk purchasing. By focusing on technical compliance, verifying purity metrics, and establishing relationships with top-tier suppliers, pharmaceutical companies can secure the materials needed for successful drug development campaigns. Always ensure that the selected vendor can provide batch-to-batch consistency and full regulatory documentation to support filing requirements.