(S)-1-Boc-3-hydroxypiperidine
- CAS No.143900-44-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity (S)-1-Boc-3-hydroxypiperidine (≥99.0%) is a key chiral building block used in the synthesis of advanced pharmaceutical intermediates, including Ibrutinib.
Request Bulk PricingProduct Technical Details
Product Overview
(S)-1-Boc-3-hydroxypiperidine is a high-value chiral intermediate widely employed in modern medicinal chemistry for the synthesis of complex active pharmaceutical ingredients (APIs). This compound features a protected piperidine ring with a stereospecific hydroxyl group at the 3-position, making it an essential scaffold in the construction of kinase inhibitors and other targeted therapeutics.
Specifications
| Molecular Formula | C₁₀H₁₉NO₃ |
|---|---|
| Molecular Weight | 201.26 g/mol |
| CAS Number | 143900-44-1 |
| Appearance | Colorless viscous liquid or white solid |
| Purity (GC/HPLC) | ≥99.0% |
| Moisture (KF) | ≤0.5% |
| Melting Point | 34–40°C |
| Boiling Point | 292.3°C |
| Density | 1.107 g/cm³ |
| Refractive Index | 1.495 |
| Flash Point | 110°C |
Industrial Applications
This enantiomerically pure intermediate plays a critical role in the multi-step synthesis of Ibrutinib, a clinically approved Bruton’s tyrosine kinase (BTK) inhibitor used in oncology. Its Boc-protected amine and free hydroxyl functionality enable selective derivatization under mild conditions, supporting efficient and scalable API manufacturing processes.
- Serves as a chiral synthon in kinase inhibitor development
- Compatible with standard peptide coupling and deprotection protocols
- Enables stereocontrolled functionalization for complex molecule assembly
Stored in a cool, well-ventilated area away from moisture and oxidizing agents, (S)-1-Boc-3-hydroxypiperidine is typically supplied in 25 kg drums or customized packaging per client specifications. Note: Supply is restricted in regions where applicable patents are in force.
