Industrial Purity Specifications and Technical Data for 2-Bromoethyl Ethyl Ether
- Critical Physical Constants: Boiling point ranges strictly between 125°C and 127°C with a density of approximately 1.357 g/mL.
- Quality Assurance: Industrial grades require rigorous GC analysis to ensure assay levels exceed 98% for pharmaceutical intermediates.
- Safety Profile: Classified as highly flammable with significant vapor hazards; requires grounded equipment and inert atmosphere storage.
In the realm of fine chemical synthesis and pharmaceutical manufacturing, the consistency of alkylating agents is paramount. 2-Bromoethyl Ethyl Ether (CAS: 592-55-2) serves as a critical building block for various organic transformations, particularly in the introduction of ethoxyethyl groups. For process chemists and procurement managers, understanding the nuance between laboratory-grade reagents and true industrial purity specifications is essential for maintaining reaction yields and safety standards. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. adheres to strict quality control protocols to ensure bulk supplies meet the demanding requirements of large-scale production.
Physical Properties and Chemical Identification
Accurate identification is the first step in quality verification. Also known by its IUPAC name 1-bromo-2-ethoxyethane, this compound is a colorless liquid that may develop a brownish tint upon prolonged exposure to light or air due to oxidation. The physical constants provided below represent the standard acceptance criteria for high-grade industrial batches. Deviations in these values often indicate the presence of residual solvents, unreacted starting materials, or degradation products.
| Parameter | Specification Range | Test Method |
|---|---|---|
| CAS Number | 592-55-2 | N/A |
| Molecular Formula | C4H9BrO | N/A |
| Molecular Weight | 153.02 g/mol | Calculated |
| Boiling Point | 125°C to 127°C | Distillation |
| Density | 1.3570 g/mL at 25°C | Pychnometry |
| Refractive Index | 1.4435 to 1.4515 | Refractometry |
| Assay (GC) | > 98.0% (Industrial Grade) | Gas Chromatography |
| Appearance | Colorless to Pale Yellow Liquid | Visual |
Manufacturing Process and Impurity Profiles
The manufacturing process for this ether typically involves the bromination of ethyl ether derivatives or the reaction of ethylene oxide with ethanol followed by bromination. The efficiency of the synthesis route directly impacts the impurity profile. Common impurities include residual ethanol, dibromoethane, and polymeric ethers. In high-quality batches, the water content must be minimized, typically below 0.1%, to prevent hydrolysis during storage or unintended side reactions during downstream processing.
For pharmaceutical applications, the presence of peroxides is a critical safety and quality concern. Ethers are prone to auto-oxidation upon exposure to atmospheric oxygen. Therefore, industrial suppliers must stabilize the product with appropriate inhibitors or supply it under inert gas padding. When evaluating a supplier, buyers should request a comprehensive COA that includes peroxide values alongside the standard assay data. NINGBO INNO PHARMCHEM CO.,LTD. ensures that all bulk shipments are tested for stability parameters to guarantee safety during transport and storage.
Safety Handling and Reactivity Considerations
From a process safety standpoint, this chemical is classified as highly flammable with a flash point around 21°C. Vapors are heavier than air and can travel to ignition sources, creating a flash-back hazard. In large-scale operations, engineering controls must be in place to manage vapor accumulation. All equipment used during handling must be grounded to prevent static discharge, which could ignite vapors.
Health and Environmental Hazards
Direct contact with the liquid can cause severe skin and eye irritation. Inhalation of vapors may lead to respiratory irritation, dizziness, or asphyxiation in confined spaces. Proper personal protective equipment (PPE), including chemical-resistant gloves, safety goggles, and respiratory protection, is mandatory during drum handling or sampling. Furthermore, runoff from fire control or spill containment must be prevented from entering waterways, as the material poses an environmental contamination risk.
Storage and Stability
To maintain industrial purity over time, containers should be stored in a cool, well-ventilated area away from direct sunlight and strong oxidizing agents. Containers must be kept tightly closed when not in use. For long-term storage, nitrogen blanketing is recommended to suppress peroxide formation. Buyers should inspect containers for integrity upon receipt and verify the manufacturing date to ensure the material has not degraded.
Procurement and Bulk Supply Standards
Sourcing reliable intermediates is crucial for maintaining supply chain continuity in pharmaceutical production. When evaluating bulk price structures, procurement officers must consider the total cost of ownership, which includes purity levels, packaging integrity, and logistical support. Lower-priced options often correlate with wider boiling point ranges or higher impurity loads, which can negatively impact downstream reaction yields and purification costs.
For facilities requiring consistent quality for organic synthesis, verifying the supply chain is essential. When sourcing high-purity 2-Bromoethyl Ethyl Ether, buyers should prioritize manufacturers who provide batch-specific documentation and retain samples for traceability. The ability to supply in various packaging configurations, from stainless steel drums to ISO tanks, is also a key indicator of a capable partner.
Verification Checklist for Buyers
- Identity Confirmation: Verify IR spectrum and refractive index match internal standards.
- Purity Assay: Ensure GC purity meets the specific threshold required for your reaction kinetics.
- Water Content: Confirm Karl Fischer titration results are within acceptable limits (typically <0.1%).
- Safety Data: Review the latest Safety Data Sheet (SDS) for updated hazard classifications and handling instructions.
Conclusion
In summary, the technical specifications of Ethane 1-bromo-2-ethoxy- derivatives demand rigorous attention to detail regarding purity, stability, and safety. By partnering with an experienced manufacturer like NINGBO INNO PHARMCHEM CO.,LTD., organizations can secure a reliable supply of intermediates that meet exacting industrial standards. Prioritizing verified quality data over initial cost savings ensures smoother production runs and higher final product quality.