Industrial Purity Methyl 2-Aminobenzoate Specifications for Bulk Procurement

• Assay Standard: Minimum 98.0% purity verified by HPLC and GC analysis for pharmaceutical-grade applications.
• Physical Constants: Boiling point 256.0°C and melting point 24°C ensure stable storage and processing.
• Supply Chain: Direct bulk procurement available with full regulatory documentation and customized packaging.

In the landscape of fine chemical manufacturing, maintaining strict control over intermediate specifications is paramount for downstream synthesis success. Methyl 2-Aminobenzoate, frequently referred to in industry literature as Methyl anthranilate, serves as a critical building block for pharmaceuticals, agrochemicals, and flavoring agents. For process chemists and procurement managers, understanding the nuanced physical and chemical properties of this ester is essential for optimizing reaction yields and ensuring final product safety. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. adheres to rigorous quality standards to deliver consistent industrial purity across large-scale batches.

Technical Specifications and Physical Properties

Accurate physical data is the foundation of process design. Whether utilizing this compound for esterification reactions or as a precursor in heterocyclic synthesis, knowing the exact thermal and density profiles prevents equipment failure and ensures safety. The following table outlines the critical technical parameters derived from standardized testing protocols.

Parameter	Specification
Chemical Name	2-Aminobenzoic Acid Methyl Ester
CAS Registry Number	134-20-3
Molecular Formula	C8H9NO2
Molecular Weight	151.16 g/mol
Appearance	Colorless to pale yellow liquid
Assay (Purity)	≥ 98.0% (GC/HPLC)
Boiling Point	256.0 ± 0.0 °C at 760 mmHg
Melting Point	24 °C (lit.)
Density	1.2 ± 0.1 g/cm³
Flash Point	104.4 ± 0.0 °C
Refractive Index	1.566

These values are critical for distillation planning and storage logistics. The boiling point of 256.0°C indicates that vacuum distillation is often preferred during purification to prevent thermal degradation. Furthermore, the flash point of 104.4°C classifies the material as combustible, necessitating strict adherence to safety protocols during bulk handling and transport.

Synthesis Route and Manufacturing Process

The commercial viability of this intermediate often depends on the efficiency of the synthesis route employed. The most common industrial method involves the Fischer esterification of anthranilic acid with methanol in the presence of an acid catalyst. Optimization of this manufacturing process focuses on maximizing conversion rates while minimizing the formation of side products such as unreacted acid or dimethyl esters.

Advanced production facilities utilize continuous flow reactors to enhance heat transfer and reaction control, resulting in higher consistency compared to batch processing. Impurity profiling is conducted at multiple stages. Key impurities monitored include residual methanol, anthranilic acid, and various isomeric byproducts. Maintaining low levels of these contaminants is vital for clients using the material in sensitive catalytic processes where poisonings can occur.

Quality Control and COA Requirements

For bulk shipments, the Certificate of Analysis (COA) is the primary document verifying compliance with agreed specifications. A comprehensive COA for methyl o-amino-benzoate should include data on identity confirmation (via IR or NMR), assay purity, and limits for heavy metals and residual solvents. High-performance liquid chromatography (HPLC) is the standard method for quantifying the main peak area, ensuring the assay meets the ≥98.0% threshold required for pharmaceutical intermediates.

When evaluating suppliers for Methyl 2-Aminobenzoate, buyers should request sample batches to verify these parameters against their internal QC standards. Consistency between batches is often more valuable than a single high-purity result, as fluctuating impurity profiles can disrupt downstream synthesis scales.

Commercial Considerations and Bulk Pricing

Procurement strategies for fine chemicals must balance cost with reliability. The bulk price of this ester is influenced by raw material costs, specifically anthranilic acid and methanol, as well as energy costs associated with distillation. Long-term supply agreements often secure more favorable pricing tiers and guarantee allocation during periods of high market demand.

Packaging options typically include 200kg drums or ISO tanks for large volumes, designed to prevent moisture ingress and oxidation. Proper labeling according to GHS standards is mandatory, indicating hazard statements such as H315 (Causes skin irritation) and H319 (Causes serious eye irritation). Logistics partners must be certified for handling combustible liquids to ensure safe delivery to port or facility.

Applications in Pharma and Flavor Industries

Beyond its role as a synthetic intermediate, this compound, also known as Methylaminobenzoate, has significant applications in the flavor and fragrance sector due to its grape-like odor profile. However, in the pharmaceutical context, its utility lies in the construction of complex heterocyclic systems. The amino group allows for diazotization and coupling reactions, while the ester moiety can be hydrolyzed or reduced depending on the target molecule architecture.

NINGBO INNO PHARMCHEM CO.,LTD. supports these diverse applications by providing technical data sheets that cover both regulatory compliance and chemical performance. By integrating robust quality assurance with efficient logistics, we ensure that our partners receive materials that meet the exacting demands of modern chemical synthesis.

Conclusion

Securing a reliable supply of high-purity intermediates is a strategic advantage in chemical manufacturing. With verified physical constants, transparent QC processes, and a commitment to consistent industrial purity, manufacturers can mitigate production risks. Understanding the technical specifications outlined above empowers procurement teams to make informed decisions that align with both operational safety and commercial efficiency.