Industrial Purity Ethyl Chlorofluoroacetate COA: Technical Specifications and Bulk Procurement
- Verified Specifications: CAS 401-56-9 with confirmed boiling point at 133 °C and density of 1.212 g/mL.
- Quality Assurance: Comprehensive COA includes GC/HPLC data, NMR spectra, and third-party lab validation.
- Bulk Supply: Scalable manufacturing process with lead times under 7 days for large-volume orders.
In the realm of fine chemical synthesis, particularly within the pharmaceutical and agrochemical sectors, the reliability of fluorinated intermediates is paramount. Ethyl Chlorofluoroacetate (CAS: 401-56-9) serves as a critical building block for introducing chlorofluoroacetyl moieties into complex molecular structures. Procuring this reagent requires more than just a purchase order; it demands a rigorous verification of the Certificate of Analysis (COA) to ensure industrial purity standards are met. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. emphasizes transparency in technical data to safeguard downstream reaction yields.
This document outlines the essential parameters buyers must evaluate when sourcing Chlorofluoroacetic Acid Ethyl Ester. Understanding the nuances of the manufacturing process and quality control protocols ensures that the material performs consistently in sensitive nucleophilic substitutions and esterifications.
Understanding Certificate of Analysis (COA) for Ethyl Chlorofluoroacetate
A robust COA is the cornerstone of chemical procurement. For ethyl 2-chloro-2-fluoroacetate, the document must extend beyond basic identity confirmation. It should provide detailed quantitative data regarding impurities that could catalyze unwanted side reactions or degrade sensitive catalysts in subsequent steps. Key elements of a compliant COA include:
- Identity Confirmation: Verification via FTIR and NMR (1H, 13C, 19F) to confirm the structural integrity of the Acetic acid chlorofluoro ethyl ester backbone.
- Purity Assay: Gas Chromatography (GC) or High-Performance Liquid Chromatography (HPLC) results indicating purity levels typically exceeding 98.0% for industrial applications.
- Impurity Profile: Specific limits on residual starting materials, such as chlorofluoroacetic acid or ethanol, which can interfere with stoichiometry.
- Physical Constants: Recorded boiling point, density, and refractive index matching literature values for CAS 401-56-9.
When evaluating suppliers, it is crucial to request a sample COA before committing to a bulk price agreement. This allows technical teams to validate that the specification sheet aligns with the actual material performance in pilot-scale reactors.
Key Purity Parameters for Pharmaceutical-Grade CAS 401-56-9
The efficacy of Ethyl Chlorofluoroacetate in synthesis is directly correlated to its purity profile. Halogenated esters are susceptible to hydrolysis and thermal degradation. Therefore, the following physical and chemical parameters are strictly monitored during quality control:
| Parameter | Standard Specification | Test Method |
|---|---|---|
| CAS Number | 401-56-9 | Registry Verification |
| Molecular Formula | C4H6ClFO2 | Calculated |
| Molecular Weight | 140.54 g/mol | Calculated |
| Purity (GC Area %) | > 98.0% | Gas Chromatography |
| Boiling Point | 133 °C (lit.) | Distillation |
| Density | 1.212 g/mL at 25 °C | Densitometry |
| Refractive Index | Matches Standard | Refractometry |
| Water Content | < 0.1% | Karl Fischer Titration |
Maintaining low water content is critical, as moisture can lead to the hydrolysis of the ester bond, generating chlorofluoroacetic acid. This acidic impurity can corrode reactor equipment and alter the pH balance of reaction mixtures. Advanced manufacturers utilize molecular sieves during the final distillation stage to ensure the industrial purity required for high-value API synthesis.
Quality Control Protocols in Bulk Fluorinated Ester Manufacturing
The synthesis route for this fluorinated intermediate involves precise halogenation and esterification steps. To guarantee consistency, rigorous quality control protocols are implemented at every stage of production. Raw materials are strictly selected to minimize the introduction of heavy metals or non-volatile residues. During the manufacturing process, in-process controls (IPC) monitor the conversion rates to prevent over-halogenation or decomposition.
For buyers seeking reliable supply chains, partnering with a dedicated entity like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to comprehensive technical documentation. This includes not only the COA but also the Material Safety Data Sheet (MSDS), Route of Synthesis (ROS), and Method of Analysis (MOA). These documents are essential for regulatory filings and customs clearance in international trade.
When sourcing high-purity Ethyl Chlorofluoroacetate, buyers should verify that the supplier employs third-party laboratory validation. Independent testing confirms that the internal QC data matches external standards, providing an additional layer of security for large-scale procurement.
Commercial Terms and Logistics for Hazardous Chemicals
Procuring fluorinated esters involves navigating complex logistics due to their classification as flammable and corrosive substances. CAS 401-56-9 typically carries a UN number of UN 2920, requiring specialized packaging and shipping documentation. Professional logistic support is essential to ensure fast and safe export compliance.
Lead Time and Availability
Market demand for fluorinated building blocks fluctuates based on pharmaceutical production cycles. Reliable manufacturers maintain stock for sample orders to facilitate rapid testing. For bulk production, a lead time of approximately 7 days is standard for established contracts. This agility allows downstream manufacturers to maintain continuous production schedules without inventory bottlenecks.
Pricing and Payment Security
The bulk price of Chlorofluoroacetic Acid Ethyl Ester is influenced by raw material costs, particularly fluorine sources, and energy consumption during distillation. Competitive pricing structures often include volume-based discounts. Secure payment terms and refund policies in the event of quality discrepancies are standard practices among reputable suppliers to protect buyer interests.
Safety and Handling
Personnel handling this material must adhere to strict safety protocols. The substance is classified with GHS symbols for flammability and corrosion. Appropriate Personal Protective Equipment (PPE), including face shields, gloves, and type ABEK respirator filters, is mandatory. Storage should be maintained at 2-8°C in a cool, dry, and well-ventilated area away from incompatible materials such as strong oxidizers and bases.
Conclusion
Securing a reliable supply of ethyl 2-chloro-2-fluoroacetate is a strategic decision that impacts the efficiency and safety of chemical manufacturing. By prioritizing vendors who provide detailed COAs, validate purity through advanced chromatography, and offer robust logistic support, procurement managers can mitigate risk. NINGBO INNO PHARMCHEM CO.,LTD. stands ready to support global partners with high-quality intermediates, ensuring that every batch meets the rigorous demands of modern synthetic chemistry.