Industrial Grade 2-Amino-5-bromothiazole Monohydrobromide Specifications and Procurement

• High Purity Standards: Consistent batches meeting ≥98% purity via HPLC analysis for pharmaceutical intermediates.
• Bulk Supply Capability: Scalable packaging from 5kg samples to 1-ton super sacks for industrial manufacturing.
• Technical Support: Comprehensive COA documentation and safety data sheets provided with every shipment.

In the landscape of pharmaceutical intermediate manufacturing, precise chemical specifications are paramount for ensuring downstream reaction success. 2-Amino-5-bromothiazole monohydrobromide (CAS: 61296-22-8) serves as a critical building block in the synthesis of various bioactive compounds, including sulfonamides and heterocyclic drugs. As a leading global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. prioritizes the delivery of this reagent with strict adherence to industrial purity standards and regulatory compliance.

Procurement teams often face challenges regarding batch consistency and impurity profiles when sourcing halogenated thiazole derivatives. Market data indicates significant price volatility for small-pack research quantities, highlighting the economic advantage of securing bulk contracts directly from established production facilities. This article details the technical specifications, quality assurance protocols, and commercial considerations for sourcing this key intermediate.

Technical Specifications and Physical Properties

Understanding the physicochemical properties of 5-bromo-1,3-thiazol-2-amine hydrobromide is essential for process chemists designing scale-up protocols. The hydrobromide salt form offers improved stability and handling characteristics compared to the free base, particularly during storage and transport. The following table outlines the critical parameters required for quality control verification.

Parameter	Specification
Chemical Name	2-Amino-5-bromothiazole Monohydrobromide
CAS Number	61296-22-8
Molecular Formula	C3H3BrN2S·HBr
Molecular Weight	259.95 g/mol
Appearance	White to off-white crystalline powder
Melting Point	163°C - 165°C (decomposition)
Purity (HPLC)	≥ 98.0% (Industrial Grade)
Storage Conditions	Inert atmosphere, 2-8°C, protected from light

Quality Assurance and Industrial Purity

Maintaining industrial purity is not merely about achieving a high percentage assay; it involves controlling specific impurities that could poison catalysts or interfere with subsequent coupling reactions. Our quality control department utilizes advanced analytical techniques, including HPLC, GC-MS, and elemental analysis, to verify composition. Every batch is accompanied by a comprehensive COA (Certificate of Analysis) that details residual solvents, heavy metals, and related substances.

For pharmaceutical applications, the presence of isomeric impurities or unreacted starting materials must be minimized. Standard market offerings often vary between 95% and 99% purity. However, for GMP-grade synthesis, tighter specifications are required. NINGBO INNO PHARMCHEM CO.,LTD. ensures that our production lines are optimized to consistently deliver material that meets these rigorous demands, reducing the need for costly recrystallization steps by the end user.

Manufacturing Process and Synthesis Optimization

The production of this thiazole derivative typically involves the bromination of 2-aminothiazole or cyclization reactions involving thiourea derivatives. The efficiency of the manufacturing process directly impacts the final cost and environmental footprint. Process chemists focus on maximizing yield while minimizing the formation of dibromo by-products.

When evaluating suppliers, it is crucial to understand their capability to manage exothermic reactions and handle corrosive reagents safely. Optimizing the synthesis route ensures higher throughput and better control over particle size distribution, which affects solubility in downstream processes. Our facility employs closed-system reactors to manage hydrogen bromide evolution, ensuring both operator safety and environmental compliance.

Commercial Packaging and Bulk Pricing

While research-grade suppliers often list prices per gram or 5g units, industrial procurement requires a focus on cost-per-kilogram at scale. Market intelligence suggests that small-pack pricing can exceed $100 per kilogram equivalent, whereas bulk contracts significantly reduce the bulk price burden. We offer flexible packaging solutions tailored to logistics requirements:

• Sample Quantities: 100g to 1kg in double-sealed polyethylene bags within aluminum foil pouches.
• Pilot Scale: 5kg to 25kg in fiber drums with polyethylene liners.
• Industrial Scale: 100kg to 1000kg in super sacks or palletized drums for FCL shipments.

For hygroscopic materials, we provide vacuum packaging or argon flushing to prevent degradation during transit. This attention to packaging detail preserves the integrity of the 2-Thiazolamine 5-bromo monohydrobromide salt, ensuring it arrives at the customer's facility ready for immediate use without additional drying steps.

Safety and Handling Guidelines

Safety is a cornerstone of industrial chemical handling. This compound is classified with specific hazard statements that require appropriate personal protective equipment (PPE). Based on GHS standards, the material carries a Warning signal word.

Safety Parameter	Details
GHS Symbol	GHS07 (Warning)
Hazard Statements	H302 (Harmful if swallowed), H319 (Causes serious eye irritation)
Precautionary Statements	P260 (Do not breathe dust), P305+P351+P338 (IF IN EYES: Rinse cautiously)
RTECS Number	XJ1262200
HS Code	2934.10.0090

Storage should be conducted in a cool, dry, well-ventilated area away from incompatible materials such as strong oxidizing agents. Containers must be kept tightly closed to prevent moisture uptake, which can lead to caking or hydrolysis over time.

Conclusion

Securing a reliable supply chain for critical intermediates like 2-Amino-5-bromothiazole Monohydrobromide is vital for maintaining production schedules in the pharmaceutical industry. By partnering with a dedicated global manufacturer like NINGBO INNO PHARMCHEM CO.,LTD., clients gain access to superior technical support, consistent quality, and competitive commercial terms. We invite procurement managers and process chemists to request samples and discuss custom specifications to meet their specific project needs.