Resolving Pd Deactivation in 5-Bromo-2,3-Dichloropyridine

Neutralizing <50 ppm Sulfur Impurities from Upstream Chlorination Steps to Prevent Pd(0) Catalyst Poisoning

Trace sulfur species originating from upstream chlorination or bromination steps are a primary vector for Pd(0) catalyst deactivation in Buchwald-Hartwig couplings. Even at concentrations below 50 ppm, organosulfur compounds coordinate irreversibly