Intermediates

5-Bromo-2,3-dichloropyridine

  • CAS No.97966-00-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 5-Bromo-2,3-dichloropyridine (CAS 97966-00-2) designed for advanced organic synthesis. Reliable supply for pharmaceutical and agrochemical R&D.

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Product Technical Details

Product Overview

5-Bromo-2,3-dichloropyridine represents a critical building block in the realm of advanced organic synthesis and medicinal chemistry. As a halogenated pyridine derivative, this compound offers unique reactivity profiles due to the presence of both bromine and chlorine substituents on the pyridine ring. Our facility specializes in the production of this high-value intermediate, ensuring consistent quality for research and industrial applications. The strategic positioning of halogen atoms allows for selective cross-coupling reactions, making it an indispensable tool for chemists developing complex molecular structures.

We understand the stringent requirements of modern pharmaceutical and agrochemical development. Therefore, our manufacturing process adheres to rigorous quality control standards. Each batch is thoroughly analyzed to confirm identity and purity, ensuring that researchers can rely on our materials for critical synthesis steps. Whether used in the discovery phase or scaled for production, this compound serves as a foundational element for creating diverse heterocyclic systems.

Specifications and Physical Properties

Transparency in product specifications is vital for our partners. The following table outlines the key physical and chemical properties of our 5-Bromo-2,3-dichloropyridine. These parameters are verified using advanced analytical techniques including HPLC and NMR spectroscopy.

ParameterValue
CAS Number97966-00-2
Molecular FormulaC5H2BrCl2N
Molecular Weight226.886 g/mol
AppearanceWhite powder
Assay (Purity)≥98.0%
Melting Point35-37 °C
Boiling Point233.6±35.0 °C at 760 mmHg
Density1.8±0.1 g/cm3
Flash Point95.1±25.9 °C

Industrial Applications

This halogenated pyridine is primarily utilized as a versatile intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemical compounds. The bromine atom typically serves as a handle for palladium-catalyzed coupling reactions such as Suzuki-Miyaura or Buchwald-Hartwig aminations. Meanwhile, the chlorine atoms can be selectively displaced under specific conditions, allowing for stepwise functionalization of the pyridine core. This flexibility makes it highly valuable for constructing kinase inhibitors, antiviral agents, and crop protection molecules.

Our clients leverage this building block to accelerate their drug discovery pipelines. By providing a reliable source of high-purity material, we help reduce variability in synthesis outcomes. This consistency is crucial when optimizing reaction conditions or scaling up processes from laboratory to pilot plant levels. Furthermore, the compound's stability under standard storage conditions ensures long shelf life without significant degradation.

Quality Assurance and Packaging

Quality is the cornerstone of our operation. Every production run undergoes multiple checkpoints to ensure compliance with specified assays. We provide a Certificate of Analysis (COA) with every shipment, detailing the results of our internal testing protocols. This documentation supports regulatory filings and quality audits for our customers. Our commitment to industrial purity means minimizing impurities that could interfere with downstream reactions or catalytic processes.

Regarding logistics, we offer flexible packaging solutions to meet diverse needs. The standard package is a 25 kg drum, which is suitable for most industrial requirements. However, we can accommodate custom packaging requests based on specific customer requirements. Proper packaging ensures the product remains protected from moisture and physical damage during transit. Our global shipping network facilitates timely delivery to research centers and manufacturing facilities worldwide.

Storage and Handling

To maintain optimal quality, 5-Bromo-2,3-dichloropyridine should be stored in a cool, ventilated place. It is essential to keep the container tightly closed when not in use to prevent exposure to atmospheric moisture. Standard laboratory safety practices should be followed during handling, including the use of appropriate personal protective equipment. By adhering to these storage guidelines, users can ensure the material retains its specified properties throughout its usage lifecycle.