N-Boc-4,4-Difluoro-L-Proline for Aurora Kinase Inhibitor Synthesis

Mitigating Steric Clashes from the Gem-Difluoro Pyrrolidine Ring in Solution-Phase Aurora Kinase Inhibitor Synthesis

When integrating a Fluorinated Proline Derivative into solution-phase peptide coupling, the gem-difluoro substitution at the C4 position introduces significant steric bulk that directly impacts nucleophilic