L(+)-Diethyl L-Tartrate for Chiral Pharma Synthesis
Technical Specifications and Purity Grades of L(+)-Diethyl L-Tartrate for Chiral Synthesis
In asymmetric synthesis, the chiral auxiliary L(+)-Diethyl L-Tartrate (CAS 87-91-2) is a workhorse for constructing enantiomerically pure intermediates. As a diethyl (2R,3R)-2,3-dihydroxybutanedioate, its stereochemical integrity directly impacts the enantiomeric excess of downstream APIs. Our product is manufactured under strict quality protocols to ensure consistent performance in reactions such as Sharpless epoxidations and kinetic resolutions. The standard industrial grade is a colorless to pale yellow liquid with a minimum assay of 99.0% (GC). For more demanding applications, a high-purity grade with assay ≥99.5% and optical rotation tightly controlled between +7.5° and +8.5° (neat) is available. This grade is particularly suited for synthesizing intermediates like those used in posaconazole, where even minor optical rotation drift can affect crystallization yields. For a deeper dive into this specific application, see our article on sourcing L(+)-Diethyl L-Tartrate for posaconazole synthesis and managing optical rotation drift.
| Parameter | Industrial Grade | High-Purity Grade |
|---|---|---|
| Assay (GC) | ≥99.0% | ≥99.5% |
| Optical Rotation [α]D20 (neat) | +7.0° to +9.0° | +7.5° to +8.5° |
| Water Content (KF) | ≤0.5% | ≤0.2% |
| Appearance | Colorless to pale yellow liquid | Colorless liquid |
These specifications are typical; please refer to the batch-specific COA for exact values. Our product serves as a seamless drop-in replacement for any standard L-DET source, matching the performance of original brands while offering significant cost advantages and reliable supply from our dedicated manufacturing lines.
Batch-Specific COA Parameters and Non-Standard Field Behavior
Beyond the standard certificate of analysis, field experience reveals critical non-standard parameters that can affect process robustness. One such behavior is the viscosity shift at sub-zero temperatures. While L(+)-Diethyl L-Tartrate remains liquid at room temperature, its viscosity increases noticeably below 0°C. In unheated storage or during winter transport, this can lead to pumping difficulties and inaccurate metering. Our logistics team addresses this proactively; for detailed guidance, refer to our bulk L(+)-Diethyl L-Tartrate logistics guide covering winter viscosity anomalies and drum pumpability. Another field observation concerns trace impurities that can impart a slight yellow tint even when GC assay is within spec. This coloration often stems from ppm-level iron or oxidation byproducts and, while not affecting most reactions, can be a concern for color-sensitive processes. Our high-purity grade undergoes additional purification to ensure a water-white appearance. Crystallization is rarely an issue, but if the product is exposed to extreme cold (< -20°C) for prolonged periods, partial solidification may occur. Gentle warming to 25–30°C with agitation restores homogeneity without degradation. These insights come from years of hands-on technical support and are essential for seamless scale-up.
Industrial-Scale Bulk Packaging and Logistics for Drop-in Replacement
For bulk procurement, we offer standard packaging in 210L HDPE drums (net weight 200 kg) and 1000L IBC totes (net weight 1000 kg). All containers are nitrogen-blanketed to maintain product integrity during storage and transit. Our logistics network is optimized for global delivery, with a focus on secure, on-time shipments. As a drop-in replacement, our L(+)-Diethyl L-Tartrate requires no changes to your existing handling or storage protocols. The product is classified as non-hazardous for transport, simplifying documentation and reducing freight costs. We maintain strategic inventory in key regions to support just-in-time delivery, minimizing your working capital exposure. For tonnage orders, dedicated tanker trucks or ISO tank containers can be arranged. Every shipment includes a comprehensive COA and, upon request, a statement of GMP compliance for pharmaceutical intermediates.
Comparative Performance Metrics as a Cost-Efficient Chiral Building Block
When evaluated as a DET chiral auxiliary, our product delivers equivalent or superior performance to higher-priced alternatives. In Sharpless epoxidation of allylic alcohols, the enantiomeric excess achieved with our L-DET is consistently >95%, matching the results obtained with premium brands. The key advantage lies in the total cost of ownership: competitive bulk pricing, reliable supply, and technical support that helps optimize reaction conditions. The table below summarizes comparative performance in a model reaction.
| Parameter | Our L-DET | Competitor A | Competitor B |
|---|---|---|---|
| Enantiomeric Excess (Sharpless Epoxidation) | 96% | 96% | 95% |
| Typical Lead Time (Bulk) | 2–3 weeks | 4–6 weeks | 3–4 weeks |
| Relative Cost Index | 100 | 115 | 108 |
These metrics are based on internal benchmarking and customer feedback. By choosing our product, you secure a robust supply chain without compromising on quality. Our technical team can assist with method transfer and process optimization to ensure a smooth transition.
Frequently Asked Questions
What is the minimum order quantity (MOQ) for L(+)-Diethyl L-Tartrate?
Our standard MOQ is one 210L drum (200 kg net). For trial or R&D purposes, smaller quantities can be arranged upon request. Contact our sales team for sample availability.
Do you provide a Certificate of Analysis (COA) with each shipment?
Yes, every batch is accompanied by a detailed COA listing assay, optical rotation, water content, and appearance. Additional tests such as heavy metals or residual solvents can be included per customer requirements.
Is your product suitable as a drop-in replacement for other brands?
Absolutely. Our L(+)-Diethyl L-Tartrate is manufactured to match the specifications of leading brands, ensuring seamless substitution without process adjustments. We recommend a small-scale verification trial to confirm compatibility with your specific synthesis.
What are the recommended storage conditions?
Store in a cool, dry, well-ventilated area away from incompatible materials. Keep containers tightly closed and under nitrogen if possible. Recommended storage temperature is 15–25°C. Avoid prolonged exposure to temperatures below 0°C to prevent viscosity increase.
Can you support custom packaging or labeling?
Yes, we offer custom labeling and packaging options for bulk orders. This includes private labeling, custom drum sizes, and specific documentation packages. Please discuss your requirements with our logistics team.
Sourcing and Technical Support
As a dedicated manufacturer of L(+)-Diethyl L-Tartrate, NINGBO INNO PHARMCHEM combines deep chemical expertise with a customer-centric supply chain. Our product is a proven diethyl (2R,3R)-2,3-dihydroxysuccinate source for chiral pharmaceutical synthesis, backed by rigorous quality assurance and responsive technical support. Whether you need a single drum for process development or multiple tons for commercial production, we deliver consistent quality and cost efficiency. For detailed specifications, batch samples, or a competitive quote, explore our product page: high-purity L(+)-Diethyl L-Tartrate for chiral auxiliary applications. Ready to optimize your supply chain? Reach out to our logistics team today for comprehensive specifications and tonnage availability.